Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 77155..77780 Replicon plasmid pMB9029_1
Accession NZ_CP103545
Organism Escherichia coli strain 3036

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag M5S54_RS23385 Protein ID WP_000911313.1
Coordinates 77382..77780 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID V0VCB2
Locus tag M5S54_RS23380 Protein ID WP_000450520.1
Coordinates 77155..77382 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5S54_RS23380 (77155) 77155..77382 + 228 WP_000450520.1 toxin-antitoxin system antitoxin VapB Antitoxin
M5S54_RS23385 (77382) 77382..77780 + 399 WP_000911313.1 type II toxin-antitoxin system VapC family toxin Toxin
M5S54_RS23390 (77789) 77789..79951 - 2163 WP_023352413.1 type IV conjugative transfer system coupling protein TraD -
M5S54_RS23395 (80204) 80204..80935 - 732 WP_023565183.1 conjugal transfer complement resistance protein TraT -
M5S54_RS23400 (80967) 80967..81464 - 498 WP_000605857.1 entry exclusion protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid blaCTX-M-55 / tet(A) / catA2 / sul3 / ant(3'')-Ia / floR / aac(3)-IIa / sitABCD iutA / iucD / iucC / iucB / iucA 1..132824 132824


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(8-50)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14901.15 Da        Isoelectric Point: 7.8605

>T255424 WP_000911313.1 NZ_CP103545:77382-77780 [Escherichia coli]
MLKFMLDTNICIFTIKNKPASVRERFNLNQGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRIDVLDYDAAAATHS
GQIRAELARQGRPVGPFDQMIAGHARSRGLIIVTNNTREFERVDGLRIEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8596.63 Da        Isoelectric Point: 4.7513

>AT255424 WP_000450520.1 NZ_CP103545:77155-77382 [Escherichia coli]
METTVFFSNRSQAVRLPKAVALPENVKRVEVIAVGRTRIITPAGETWDEWFDGHNVSADFMDNREQPGMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB V0VCB2

References