255415

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4186806..4187401 Replicon chromosome
Accession NZ_CP103544
Organism Escherichia coli strain 3036

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag M5S54_RS20200 Protein ID WP_000239579.1
Coordinates 4186806..4187156 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag M5S54_RS20205 Protein ID WP_001223208.1
Coordinates 4187150..4187401 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5S54_RS20180 (4182082) 4182082..4183104 - 1023 WP_001339490.1 ABC transporter permease -
M5S54_RS20185 (4183118) 4183118..4184620 - 1503 WP_000205793.1 sugar ABC transporter ATP-binding protein -
M5S54_RS20190 (4184930) 4184930..4185886 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
M5S54_RS20195 (4186196) 4186196..4186726 + 531 WP_000055072.1 inorganic diphosphatase -
M5S54_RS20200 (4186806) 4186806..4187156 - 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
M5S54_RS20205 (4187150) 4187150..4187401 - 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
M5S54_RS20210 (4187614) 4187614..4187955 - 342 WP_063100134.1 gamma-glutamylcyclotransferase -
M5S54_RS20215 (4187958) 4187958..4191737 - 3780 WP_000060901.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T255415 WP_000239579.1 NZ_CP103544:c4187156-4186806 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT255415 WP_001223208.1 NZ_CP103544:c4187401-4187150 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References