Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2470770..2471408 Replicon chromosome
Accession NZ_CP103544
Organism Escherichia coli strain 3036

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag M5S54_RS11955 Protein ID WP_000813794.1
Coordinates 2471232..2471408 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag M5S54_RS11950 Protein ID WP_001270286.1
Coordinates 2470770..2471186 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5S54_RS11930 (2465922) 2465922..2466863 - 942 WP_001251319.1 ABC transporter permease -
M5S54_RS11935 (2466864) 2466864..2467877 - 1014 WP_000220396.1 ABC transporter ATP-binding protein -
M5S54_RS11940 (2467895) 2467895..2469040 - 1146 WP_000047456.1 ABC transporter substrate-binding protein -
M5S54_RS11945 (2469285) 2469285..2470691 - 1407 WP_000760629.1 PLP-dependent aminotransferase family protein -
M5S54_RS11950 (2470770) 2470770..2471186 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
M5S54_RS11955 (2471232) 2471232..2471408 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
M5S54_RS11960 (2471630) 2471630..2471860 + 231 WP_000494244.1 YncJ family protein -
M5S54_RS11965 (2471952) 2471952..2473913 - 1962 WP_001307191.1 23S rRNA 5-hydroxycytidine C2501 synthase -
M5S54_RS11970 (2473986) 2473986..2474522 - 537 WP_000429141.1 DNA-binding transcriptional regulator SutR -
M5S54_RS11975 (2474614) 2474614..2475789 + 1176 WP_001236319.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2475829..2477094 1265


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T255410 WP_000813794.1 NZ_CP103544:c2471408-2471232 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT255410 WP_001270286.1 NZ_CP103544:c2471186-2470770 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References