Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1287316..1287941 Replicon chromosome
Accession NZ_CP103544
Organism Escherichia coli strain 3036

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag M5S54_RS06225 Protein ID WP_000911330.1
Coordinates 1287543..1287941 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag M5S54_RS06220 Protein ID WP_000450524.1
Coordinates 1287316..1287543 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5S54_RS06195 (1283119) 1283119..1283589 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
M5S54_RS06200 (1283589) 1283589..1284161 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
M5S54_RS06205 (1284307) 1284307..1285185 + 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
M5S54_RS06210 (1285202) 1285202..1286236 + 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
M5S54_RS06215 (1286449) 1286449..1287162 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
M5S54_RS06220 (1287316) 1287316..1287543 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
M5S54_RS06225 (1287543) 1287543..1287941 + 399 WP_000911330.1 type II toxin-antitoxin system VapC family toxin Toxin
M5S54_RS06230 (1288088) 1288088..1288951 + 864 WP_001267508.1 neutral zinc metallopeptidase -
M5S54_RS06235 (1288966) 1288966..1290981 + 2016 WP_000829329.1 tRNA cytosine(34) acetyltransferase TmcA -
M5S54_RS06240 (1291055) 1291055..1291753 + 699 WP_000679823.1 esterase -
M5S54_RS06245 (1291863) 1291863..1292063 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14894.25 Da        Isoelectric Point: 9.2216

>T255402 WP_000911330.1 NZ_CP103544:1287543-1287941 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT255402 WP_000450524.1 NZ_CP103544:1287316-1287543 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References