Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 863172..863826 Replicon chromosome
Accession NZ_CP103544
Organism Escherichia coli strain 3036

Toxin (Protein)


Gene name cptA Uniprot ID F4NJ21
Locus tag M5S54_RS04200 Protein ID WP_000244772.1
Coordinates 863419..863826 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID -
Locus tag M5S54_RS04195 Protein ID WP_063100142.1
Coordinates 863172..863438 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5S54_RS04170 (858460) 858460..859203 + 744 WP_000951964.1 SDR family oxidoreductase -
M5S54_RS04175 (859260) 859260..860693 - 1434 WP_001363803.1 6-phospho-beta-glucosidase BglA -
M5S54_RS04180 (860738) 860738..861049 + 312 WP_001182944.1 N(4)-acetylcytidine aminohydrolase -
M5S54_RS04185 (861213) 861213..861872 + 660 WP_000250274.1 hemolysin III family protein -
M5S54_RS04190 (861949) 861949..862929 - 981 WP_000886062.1 tRNA-modifying protein YgfZ -
M5S54_RS04195 (863172) 863172..863438 + 267 WP_063100142.1 FAD assembly factor SdhE Antitoxin
M5S54_RS04200 (863419) 863419..863826 + 408 WP_000244772.1 protein YgfX Toxin
M5S54_RS04205 (863866) 863866..864387 - 522 WP_001055874.1 flavodoxin FldB -
M5S54_RS04210 (864499) 864499..865395 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
M5S54_RS04215 (865420) 865420..866130 + 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
M5S54_RS04220 (866136) 866136..867869 + 1734 WP_000813215.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16048.02 Da        Isoelectric Point: 11.2511

>T255400 WP_000244772.1 NZ_CP103544:863419-863826 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWCIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10548.07 Da        Isoelectric Point: 5.1599

>AT255400 WP_063100142.1 NZ_CP103544:863172-863438 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFNRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XYB4

Antitoxin

Source ID Structure

References