25540

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/-
Location 2456232..2456761 Replicon chromosome
Accession NC_015848
Organism Mycobacterium canettii CIPT 140010059

Toxin (Protein)


Gene name parE Uniprot ID G0TMR4
Locus tag MCAN_RS11345 Protein ID WP_003411124.1
Coordinates 2456232..2456549 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P9WJ74
Locus tag MCAN_RS11350 Protein ID WP_003411127.1
Coordinates 2456546..2456761 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MCAN_RS11320 2452268..2452549 + 282 WP_003411112.1 hypothetical protein -
MCAN_RS11325 2452585..2453658 + 1074 WP_014001148.1 quinone-dependent dihydroorotate dehydrogenase -
MCAN_RS11330 2453663..2454193 - 531 WP_003411119.1 YbhB/YbcL family Raf kinase inhibitor-like protein -
MCAN_RS11335 2454241..2455587 - 1347 WP_014001149.1 M20/M25/M40 family metallo-hydrolase -
MCAN_RS11345 2456232..2456549 - 318 WP_003411124.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MCAN_RS11350 2456546..2456761 - 216 WP_003411127.1 antitoxin ParD2 Antitoxin
MCAN_RS11355 2457019..2458077 + 1059 WP_003411129.1 hypothetical protein -
MCAN_RS11360 2458207..2458563 - 357 WP_014001150.1 hypothetical protein -
MCAN_RS11365 2458658..2459440 - 783 WP_014001151.1 cell wall synthesis protein Wag31 -
MCAN_RS11370 2459708..2459998 - 291 WP_003900476.1 YggT family protein -
MCAN_RS11375 2460161..2460817 - 657 WP_003411133.1 cell division protein SepF -
MCAN_RS11380 2460883..2461659 - 777 WP_014001152.1 YggS family pyridoxal phosphate-dependent enzyme -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-92)

Antitoxin

Conserved hypothetical protein CHP02574, addiction module

(11-69)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12312.88 Da        Isoelectric Point: 6.4831

>T25540 WP_003411124.1 NC_015848:c2456549-2456232 [Mycobacterium canettii CIPT 140010059]
MTRRLRVHNGVEDDLFEAFSYYADAAPDQIDRLYNLFVDAVTKRIPQAPNAFAPLFKHYRHIYLRPFRYYVAYRTTDEAI
DILAVRHGMENPNAVEAEISGRTFE

Download         Length: 318 bp

>T25540 NC_015848:c2456549-2456232 [Mycobacterium canettii CIPT 140010059]
ATGACGCGCAGGCTGCGCGTCCATAACGGGGTTGAAGACGACCTATTCGAGGCGTTTTCCTACTACGCGGACGCGGCGCC
AGATCAGATCGATCGGCTTTACAACTTGTTTGTCGATGCCGTGACGAAGCGGATTCCGCAGGCTCCGAACGCGTTTGCGC
CGTTATTCAAGCACTATCGACACATCTACCTCCGGCCCTTCAGGTACTACGTTGCCTATCGGACGACCGACGAGGCTATC
GACATACTGGCTGTTCGGCACGGAATGGAGAACCCGAACGCGGTCGAGGCTGAGATCTCTGGCCGCACCTTCGAGTGA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7880.70 Da        Isoelectric Point: 4.4055

>AT25540 WP_003411127.1 NC_015848:c2456761-2456546 [Mycobacterium canettii CIPT 140010059]
VVVNRALLASVDALSRDEQIELVEHINGNLAEGMHISEANQALIEARANDTDDAHWSTIDDFDKRIRARLG

Download         Length: 216 bp

>AT25540 NC_015848:c2456761-2456546 [Mycobacterium canettii CIPT 140010059]
GTGGTGGTCAACCGGGCATTGCTGGCGAGCGTCGACGCACTGTCGCGTGATGAGCAGATTGAGCTCGTCGAGCACATCAA
CGGAAACCTAGCCGAGGGCATGCATATCAGCGAGGCCAACCAGGCGCTCATCGAAGCGCGGGCCAATGACACCGACGATG
CTCATTGGTCCACCATTGATGACTTCGACAAGCGGATCCGCGCCCGGCTCGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TMR4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FAJ4

References