Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 28732..29254 Replicon plasmid pMB9108_4
Accession NZ_CP103537
Organism Escherichia coli strain 4238

Toxin (Protein)


Gene name relE Uniprot ID G3CAN5
Locus tag M5T38_RS24970 Protein ID WP_000220560.1
Coordinates 28973..29254 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G3CAG1
Locus tag M5T38_RS24965 Protein ID WP_000121743.1
Coordinates 28732..28983 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T38_RS24945 (M5T38_24945) 24084..25148 + 1065 WP_012291478.1 ParA family protein -
M5T38_RS24950 (M5T38_24950) 25686..26039 - 354 WP_001675596.1 DNA distortion polypeptide 3 -
M5T38_RS24955 (M5T38_24955) 26176..26622 - 447 WP_001074386.1 hypothetical protein -
M5T38_RS24960 (M5T38_24960) 26662..27498 - 837 WP_001050931.1 RepB family plasmid replication initiator protein -
M5T38_RS24965 (M5T38_24965) 28732..28983 + 252 WP_000121743.1 plasmid stabilization protein Antitoxin
M5T38_RS24970 (M5T38_24970) 28973..29254 + 282 WP_000220560.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M5T38_RS24975 (M5T38_24975) 29400..29723 + 324 WP_001181903.1 hypothetical protein -
M5T38_RS24980 (M5T38_24980) 29768..30013 + 246 WP_000356546.1 hypothetical protein -
M5T38_RS24985 (M5T38_24985) 30003..30218 + 216 WP_001180116.1 hypothetical protein -
M5T38_RS24990 (M5T38_24990) 30311..30640 + 330 WP_000866648.1 hypothetical protein -
M5T38_RS24995 (M5T38_24995) 30683..30862 + 180 WP_024133577.1 hypothetical protein -
M5T38_RS25000 (M5T38_25000) 30932..31081 + 150 WP_000003880.1 hypothetical protein -
M5T38_RS25005 (M5T38_25005) 31094..31366 + 273 WP_000160399.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..31691 31691


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11005.83 Da        Isoelectric Point: 10.5938

>T255377 WP_000220560.1 NZ_CP103537:28973-29254 [Escherichia coli]
MTYELAFDRRALKEWQKLGHTIREQFKKKLAERLENPRVPAARLHGHADRYKIKLRASGYRLVYQVIDEKVVLLVIAVGR
RESSEVYQIADLR

Download         Length: 282 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9194.43 Da        Isoelectric Point: 4.1683

>AT255377 WP_000121743.1 NZ_CP103537:28732-28983 [Escherichia coli]
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPKLYAYYRELAEDAELNAVADERMKNPEIVKVNL
DDL

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G3CAN5

Antitoxin

Source ID Structure
AlphaFold DB A0A3S5I301

References