Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4337484..4337981 Replicon chromosome
Accession NZ_CP103533
Organism Escherichia coli strain 4238

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag M5T38_RS20995 Protein ID WP_001173343.1
Coordinates 4337484..4337657 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID J7RC38
Locus tag M5T38_RS21000 Protein ID WP_001425728.1
Coordinates 4337685..4337981 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T38_RS20985 (4334154) 4334154..4335611 + 1458 WP_000856841.1 dipeptide/tripeptide permease DtpC -
M5T38_RS20990 (4335848) 4335848..4337365 + 1518 WP_001295074.1 lysine--tRNA ligase -
M5T38_RS20995 (4337484) 4337484..4337657 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
M5T38_RS21000 (4337685) 4337685..4337981 - 297 WP_001425728.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
M5T38_RS21005 (4338208) 4338208..4338480 - 273 WP_000405647.1 GNAT family N-acetyltransferase -
M5T38_RS21010 (4338492) 4338492..4338722 - 231 WP_000371700.1 4Fe-4S mono-cluster protein YjdI -
M5T38_RS21015 (4338903) 4338903..4340534 + 1632 WP_001216487.1 sensor histidine kinase -
M5T38_RS21020 (4340531) 4340531..4341250 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T255367 WP_001173343.1 NZ_CP103533:c4337657-4337484 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11466.99 Da        Isoelectric Point: 4.2544

>AT255367 WP_001425728.1 NZ_CP103533:c4337981-4337685 [Escherichia coli]
MEGKNKFNTYVVSFNYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
AlphaFold DB J7RC38

References