Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3505292..3505910 Replicon chromosome
Accession NZ_CP103533
Organism Escherichia coli strain 4238

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag M5T38_RS17020 Protein ID WP_001291435.1
Coordinates 3505692..3505910 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag M5T38_RS17015 Protein ID WP_000344800.1
Coordinates 3505292..3505666 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T38_RS17005 (3500381) 3500381..3501574 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
M5T38_RS17010 (3501597) 3501597..3504746 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
M5T38_RS17015 (3505292) 3505292..3505666 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
M5T38_RS17020 (3505692) 3505692..3505910 + 219 WP_001291435.1 HHA domain-containing protein Toxin
M5T38_RS17025 (3506082) 3506082..3506633 + 552 WP_000102568.1 maltose O-acetyltransferase -
M5T38_RS17030 (3506749) 3506749..3507219 + 471 WP_000136192.1 YlaC family protein -
M5T38_RS17035 (3507383) 3507383..3508933 + 1551 WP_001372022.1 cyclic-guanylate-specific phosphodiesterase PdeB -
M5T38_RS17040 (3508975) 3508975..3509328 - 354 WP_000878140.1 DUF1428 domain-containing protein -
M5T38_RS17050 (3509707) 3509707..3510018 + 312 WP_000409911.1 MGMT family protein -
M5T38_RS17055 (3510049) 3510049..3510621 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T255365 WP_001291435.1 NZ_CP103533:3505692-3505910 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT255365 WP_000344800.1 NZ_CP103533:3505292-3505666 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References