Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2411257..2412845 Replicon chromosome
Accession NZ_CP103533
Organism Escherichia coli strain 4238

Toxin (Protein)


Gene name hipA Uniprot ID F4NFZ0
Locus tag M5T38_RS11685 Protein ID WP_001125463.1
Coordinates 2411523..2412845 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag M5T38_RS11680 Protein ID WP_001296726.1
Coordinates 2411257..2411523 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T38_RS11680 (2411257) 2411257..2411523 + 267 WP_001296726.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
M5T38_RS11685 (2411523) 2411523..2412845 + 1323 WP_001125463.1 type II toxin-antitoxin system serine/threonine protein kinase toxin HipA Toxin
M5T38_RS11690 (2413157) 2413157..2413365 + 209 Protein_2288 AraC family transcriptional regulator -
M5T38_RS11695 (2413485) 2413485..2415575 + 2091 Protein_2289 fimbrial biogenesis outer membrane usher protein -
M5T38_RS11700 (2415589) 2415589..2416119 + 531 WP_000876784.1 fimbrial protein -
M5T38_RS11705 (2416132) 2416132..2416635 + 504 WP_000825458.1 fimbrial protein -
M5T38_RS11710 (2416695) 2416695..2417609 + 915 WP_000520679.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2411257..2426132 14875


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(7-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-69)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49422.05 Da        Isoelectric Point: 9.1203

>T255364 WP_001125463.1 NZ_CP103533:2411523-2412845 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLLPENETITRPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGRVRALAVERFDRRW
NTERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALRDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLRFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVETNVLRLHGRLSREYGSK

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10047.39 Da        Isoelectric Point: 4.9632

>AT255364 WP_001296726.1 NZ_CP103533:2411257-2411523 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDTKNASPES
TEQQDLEW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9IYX0

Antitoxin

Source ID Structure

References