Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1390991..1391616 Replicon chromosome
Accession NZ_CP103533
Organism Escherichia coli strain 4238

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag M5T38_RS06810 Protein ID WP_000911330.1
Coordinates 1391218..1391616 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag M5T38_RS06805 Protein ID WP_000450524.1
Coordinates 1390991..1391218 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T38_RS06780 (1386794) 1386794..1387264 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
M5T38_RS06785 (1387264) 1387264..1387836 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
M5T38_RS06790 (1387982) 1387982..1388860 + 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
M5T38_RS06795 (1388877) 1388877..1389911 + 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
M5T38_RS06800 (1390124) 1390124..1390837 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
M5T38_RS06805 (1390991) 1390991..1391218 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
M5T38_RS06810 (1391218) 1391218..1391616 + 399 WP_000911330.1 type II toxin-antitoxin system VapC family toxin Toxin
M5T38_RS06815 (1391763) 1391763..1392626 + 864 WP_001267507.1 neutral zinc metallopeptidase -
M5T38_RS06820 (1392641) 1392641..1394656 + 2016 WP_000829323.1 tRNA cytosine(34) acetyltransferase TmcA -
M5T38_RS06825 (1394730) 1394730..1395428 + 699 WP_000679823.1 esterase -
M5T38_RS06830 (1395538) 1395538..1395738 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14894.25 Da        Isoelectric Point: 9.2216

>T255358 WP_000911330.1 NZ_CP103533:1391218-1391616 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT255358 WP_000450524.1 NZ_CP103533:1390991-1391218 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References