Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 915229..915883 Replicon chromosome
Accession NZ_CP103533
Organism Escherichia coli strain 4238

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag M5T38_RS04480 Protein ID WP_000244777.1
Coordinates 915476..915883 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag M5T38_RS04475 Protein ID WP_000354046.1
Coordinates 915229..915495 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T38_RS04450 (910517) 910517..911260 + 744 Protein_873 SDR family oxidoreductase -
M5T38_RS04455 (911317) 911317..912750 - 1434 WP_001363803.1 6-phospho-beta-glucosidase BglA -
M5T38_RS04460 (912795) 912795..913106 + 312 WP_001679467.1 N(4)-acetylcytidine aminohydrolase -
M5T38_RS04465 (913270) 913270..913929 + 660 WP_000250274.1 hemolysin III family protein -
M5T38_RS04470 (914006) 914006..914986 - 981 WP_000886062.1 tRNA-modifying protein YgfZ -
M5T38_RS04475 (915229) 915229..915495 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
M5T38_RS04480 (915476) 915476..915883 + 408 WP_000244777.1 protein YgfX Toxin
M5T38_RS04485 (915923) 915923..916444 - 522 WP_001055874.1 flavodoxin FldB -
M5T38_RS04490 (916556) 916556..917452 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
M5T38_RS04495 (917477) 917477..918187 + 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
M5T38_RS04500 (918193) 918193..919926 + 1734 WP_000813212.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T255355 WP_000244777.1 NZ_CP103533:915476-915883 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT255355 WP_000354046.1 NZ_CP103533:915229-915495 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References