Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4394979..4395574 Replicon chromosome
Accession NZ_CP103529
Organism Escherichia coli strain 5270

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag M5T24_RS21250 Protein ID WP_000239579.1
Coordinates 4394979..4395329 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag M5T24_RS21255 Protein ID WP_001223208.1
Coordinates 4395323..4395574 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T24_RS21230 (4390425) 4390425..4391447 - 1023 WP_001295197.1 ABC transporter permease -
M5T24_RS21235 (4391461) 4391461..4392963 - 1503 WP_000205784.1 sugar ABC transporter ATP-binding protein -
M5T24_RS21240 (4393103) 4393103..4394059 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
M5T24_RS21245 (4394369) 4394369..4394899 + 531 WP_000055072.1 inorganic diphosphatase -
M5T24_RS21250 (4394979) 4394979..4395329 - 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
M5T24_RS21255 (4395323) 4395323..4395574 - 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
M5T24_RS21260 (4395786) 4395786..4396127 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
M5T24_RS21265 (4396130) 4396130..4399909 - 3780 WP_000060978.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T255344 WP_000239579.1 NZ_CP103529:c4395329-4394979 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT255344 WP_001223208.1 NZ_CP103529:c4395574-4395323 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References