Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2613360..2613998 Replicon chromosome
Accession NZ_CP103529
Organism Escherichia coli strain 5270

Toxin (Protein)


Gene name hicA Uniprot ID A0A0A6TXU8
Locus tag M5T24_RS12535 Protein ID WP_001447010.1
Coordinates 2613822..2613998 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag M5T24_RS12530 Protein ID WP_001270286.1
Coordinates 2613360..2613776 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T24_RS12510 (2608512) 2608512..2609453 - 942 WP_001251304.1 ABC transporter permease -
M5T24_RS12515 (2609454) 2609454..2610467 - 1014 WP_000220396.1 ABC transporter ATP-binding protein -
M5T24_RS12520 (2610485) 2610485..2611630 - 1146 WP_000047424.1 ABC transporter substrate-binding protein -
M5T24_RS12525 (2611875) 2611875..2613281 - 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
M5T24_RS12530 (2613360) 2613360..2613776 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
M5T24_RS12535 (2613822) 2613822..2613998 - 177 WP_001447010.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
M5T24_RS12540 (2614220) 2614220..2614450 + 231 WP_000494244.1 YncJ family protein -
M5T24_RS12545 (2614542) 2614542..2616503 - 1962 WP_259426000.1 23S rRNA 5-hydroxycytidine C2501 synthase -
M5T24_RS12550 (2616576) 2616576..2617112 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
M5T24_RS12555 (2617204) 2617204..2618379 + 1176 WP_001236265.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6779.86 Da        Isoelectric Point: 11.2298

>T255339 WP_001447010.1 NZ_CP103529:c2613998-2613822 [Escherichia coli]
VKQSEFRRWLESQGVDVANSSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT255339 WP_001270286.1 NZ_CP103529:c2613776-2613360 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A6TXU8

Antitoxin

Source ID Structure

References