Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 2247691..2248235 Replicon chromosome
Accession NC_015848
Organism Mycobacterium canettii CIPT 140010059

Toxin (Protein)


Gene name parE Uniprot ID G0TLU9
Locus tag MCAN_RS10295 Protein ID WP_003409896.1
Coordinates 2247691..2247987 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID G0TLV0
Locus tag MCAN_RS10300 Protein ID WP_014001030.1
Coordinates 2247984..2248235 (-) Length 84 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MCAN_RS10245 2242721..2243071 - 351 WP_003409871.1 hypothetical protein -
MCAN_RS10250 2243082..2243984 - 903 WP_080603716.1 hypothetical protein -
MCAN_RS21435 2244005..2244197 - 193 Protein_2013 hypothetical protein -
MCAN_RS10255 2244198..2244494 - 297 WP_014001026.1 hypothetical protein -
MCAN_RS10260 2244735..2244950 + 216 WP_003409878.1 antitoxin -
MCAN_RS10265 2244947..2245258 + 312 WP_003409881.1 type II toxin-antitoxin system VapC family toxin -
MCAN_RS22805 2245232..2245753 - 522 WP_014001027.1 hypothetical protein -
MCAN_RS10275 2245728..2246105 + 378 WP_162138899.1 type II toxin-antitoxin system toxin HigB -
MCAN_RS10280 2246147..2246596 + 450 WP_003409886.1 type II toxin-antitoxin system antitoxin HigA -
MCAN_RS10285 2246593..2247138 + 546 WP_003409891.1 SecB-like chaperone -
MCAN_RS10290 2247027..2247641 - 615 WP_014001029.1 hypothetical protein -
MCAN_RS10295 2247691..2247987 - 297 WP_003409896.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MCAN_RS10300 2247984..2248235 - 252 WP_014001030.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
MCAN_RS10305 2248222..2248713 + 492 WP_014001031.1 hypothetical protein -
MCAN_RS10310 2248873..2249280 - 408 WP_003409913.1 type II toxin-antitoxin system VapC family toxin -
MCAN_RS10315 2249284..2249556 - 273 WP_003899100.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
MCAN_RS10320 2249589..2250809 - 1221 WP_014001032.1 TetR family transcriptional regulator Mce3R -
MCAN_RS10330 2251707..2252504 + 798 WP_014001033.1 ABC transporter permease -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(5-93)

Antitoxin

(2-80)


Sequences


Toxin        


Download         Length: 99 a.a.        Molecular weight: 11268.64 Da        Isoelectric Point: 6.8604

>T25532 WP_003409896.1 NC_015848:c2247987-2247691 [Mycobacterium canettii CIPT 140010059]
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL

Download         Length: 297 bp

>T25532 NC_015848:c2247987-2247691 [Mycobacterium canettii CIPT 140010059]
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9221.20 Da        Isoelectric Point: 7.0150

>AT25532 WP_014001030.1 NC_015848:c2248235-2247984 [Mycobacterium canettii CIPT 140010059]
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RAR

Download         Length: 252 bp

>AT25532 NC_015848:c2248235-2247984 [Mycobacterium canettii CIPT 140010059]
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGCCCGGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB G0TLU9


Antitoxin

Source ID Structure
AlphaFold DB G0TLV0

References