Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4617789..4618624 Replicon chromosome
Accession NZ_CP103521
Organism Escherichia coli strain 2779 - blood draw same patient as MB9267

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0J1YPH7
Locus tag M5S63_RS22475 Protein ID WP_029701676.1
Coordinates 4618247..4618624 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0K5N986
Locus tag M5S63_RS22470 Protein ID WP_021553056.1
Coordinates 4617789..4618157 (+) Length 123 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5S63_RS22435 (4613451) 4613451..4614131 + 681 WP_029702103.1 WYL domain-containing protein -
M5S63_RS22440 (4614279) 4614279..4614956 + 678 WP_001097302.1 hypothetical protein -
M5S63_RS22445 (4614962) 4614962..4615195 + 234 WP_001278293.1 DUF905 family protein -
M5S63_RS22450 (4615285) 4615285..4616103 + 819 WP_001175165.1 DUF932 domain-containing protein -
M5S63_RS22455 (4616369) 4616369..4616848 + 480 WP_001564060.1 antirestriction protein -
M5S63_RS22460 (4616864) 4616864..4617340 + 477 WP_021553055.1 RadC family protein -
M5S63_RS22465 (4617405) 4617405..4617626 + 222 WP_000692345.1 DUF987 domain-containing protein -
M5S63_RS22470 (4617789) 4617789..4618157 + 369 WP_021553056.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
M5S63_RS22475 (4618247) 4618247..4618624 + 378 WP_029701676.1 TA system toxin CbtA family protein Toxin
M5S63_RS22480 (4618621) 4618621..4618770 + 150 Protein_4400 DUF5983 family protein -
M5S63_RS22485 (4618849) 4618849..4619043 + 195 WP_024181941.1 DUF957 domain-containing protein -
M5S63_RS22490 (4619128) 4619128..4619970 + 843 WP_022645115.1 DUF4942 domain-containing protein -
M5S63_RS22495 (4620719) 4620719..4622257 + 1539 WP_001187196.1 lysine decarboxylation/transport transcriptional activator CadC -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4584269..4630069 45800


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-112)

Antitoxin

(18-117)


Sequences


Toxin        


Download         Length: 126 a.a.        Molecular weight: 14066.04 Da        Isoelectric Point: 7.8045

>T255311 WP_029701676.1 NZ_CP103521:4618247-4618624 [Escherichia coli]
MKTLPDTHVREVSCCPSPVTIWQTLLTRLLDQHYSLTLNDTPFVDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGASSQLINSIDILRARRATGLMTRSNYRTVNNITRGKHPEAKQ

Download         Length: 378 bp


Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13615.39 Da        Isoelectric Point: 7.0264

>AT255311 WP_021553056.1 NZ_CP103521:4617789-4618157 [Escherichia coli]
VSDTLSGTTHPDDNHDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGNRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A0J1YPH7


Antitoxin

Source ID Structure
AlphaFold DB A0A0K5N986

References