Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4457127..4457722 Replicon chromosome
Accession NZ_CP103521
Organism Escherichia coli strain 2779 - blood draw same patient as MB9267

Toxin (Protein)


Gene name chpB Uniprot ID V0SXT4
Locus tag M5S63_RS21600 Protein ID WP_000239581.1
Coordinates 4457127..4457477 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID L4JJX7
Locus tag M5S63_RS21605 Protein ID WP_001223213.1
Coordinates 4457471..4457722 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5S63_RS21580 (4452581) 4452581..4453603 - 1023 WP_001361374.1 ABC transporter permease -
M5S63_RS21585 (4453617) 4453617..4455119 - 1503 WP_001522399.1 sugar ABC transporter ATP-binding protein -
M5S63_RS21590 (4455252) 4455252..4456208 - 957 WP_001522398.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
M5S63_RS21595 (4456518) 4456518..4457048 + 531 WP_000055075.1 inorganic diphosphatase -
M5S63_RS21600 (4457127) 4457127..4457477 - 351 WP_000239581.1 endoribonuclease toxin ChpB Toxin
M5S63_RS21605 (4457471) 4457471..4457722 - 252 WP_001223213.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
M5S63_RS21610 (4457934) 4457934..4458275 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
M5S63_RS21615 (4458278) 4458278..4462057 - 3780 WP_001522396.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12453.41 Da        Isoelectric Point: 6.2206

>T255310 WP_000239581.1 NZ_CP103521:c4457477-4457127 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAAGEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9331.64 Da        Isoelectric Point: 4.6509

>AT255310 WP_001223213.1 NZ_CP103521:c4457722-4457471 [Escherichia coli]
MRITIKRWGNSSGMVIPNVVMKELNLRPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNATELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SXT4

Antitoxin

Source ID Structure
AlphaFold DB L4JJX7

References