Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4445586..4446108 Replicon chromosome
Accession NZ_CP103521
Organism Escherichia coli strain 2779 - blood draw same patient as MB9267

Toxin (Protein)


Gene name relE Uniprot ID A0A829L6G8
Locus tag M5S63_RS21540 Protein ID WP_001105433.1
Coordinates 4445586..4445876 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V0SC69
Locus tag M5S63_RS21545 Protein ID WP_000212715.1
Coordinates 4445866..4446108 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5S63_RS21525 (4440749) 4440749..4442404 + 1656 WP_021523332.1 alpha,alpha-phosphotrehalase -
M5S63_RS21530 (4442798) 4442798..4444936 + 2139 WP_000187798.1 anaerobic ribonucleoside-triphosphate reductase -
M5S63_RS21535 (4445121) 4445121..4445585 + 465 WP_001009182.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
M5S63_RS21540 (4445586) 4445586..4445876 - 291 WP_001105433.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M5S63_RS21545 (4445866) 4445866..4446108 - 243 WP_000212715.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
M5S63_RS21550 (4446300) 4446300..4446686 - 387 WP_001232246.1 cytochrome b562 -
M5S63_RS21555 (4446870) 4446870..4448222 - 1353 WP_001162173.1 metalloprotease PmbA -
M5S63_RS21560 (4448316) 4448316..4448867 + 552 WP_000166270.1 ribosome biogenesis factor YjgA -
M5S63_RS21565 (4449019) 4449019..4450392 - 1374 WP_001522402.1 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-72)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11367.23 Da        Isoelectric Point: 10.0238

>T255309 WP_001105433.1 NZ_CP103521:c4445876-4445586 [Escherichia coli]
MNYELAFDPRALKEWQKLGVTVREQFKKKLEDVLKRPRNPSAKLRDLPDCYKIKLRTQGYRLVYQVNDKELLVLVIAIGK
RENSAVYEDATKRLDE

Download         Length: 291 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9125.56 Da        Isoelectric Point: 5.1369

>AT255309 WP_000212715.1 NZ_CP103521:c4446108-4445866 [Escherichia coli]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAENGRMPVKTLTVSDSEEALLRTVRERLANPQEAIKVRLDEL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829L6G8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9H4B3

References