255308

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 4346324..4347138 Replicon chromosome
Accession NZ_CP103521
Organism Escherichia coli strain 2779 - blood draw same patient as MB9267

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag M5S63_RS21030 Protein ID WP_001054376.1
Coordinates 4346324..4346581 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag M5S63_RS21035 Protein ID WP_001309181.1
Coordinates 4346593..4347138 (+) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5S63_RS21005 (4341612) 4341612..4342718 + 1107 WP_204638466.1 N-acetylneuraminate epimerase -
M5S63_RS21010 (4342783) 4342783..4343763 + 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
M5S63_RS21015 (4343873) 4343873..4344078 + 206 Protein_4112 HNH endonuclease -
M5S63_RS21020 (4344346) 4344346..4345586 - 1241 Protein_4113 helicase YjhR -
M5S63_RS21025 (4345702) 4345702..4345833 + 132 WP_001309182.1 hypothetical protein -
M5S63_RS21030 (4346324) 4346324..4346581 + 258 WP_001054376.1 YjhX family toxin Toxin
M5S63_RS21035 (4346593) 4346593..4347138 + 546 WP_001309181.1 N-acetyltransferase Antitoxin
M5S63_RS21040 (4347194) 4347194..4347940 + 747 WP_000354251.1 class I SAM-dependent methyltransferase -
M5S63_RS21045 (4348109) 4348109..4348327 + 219 Protein_4118 hypothetical protein -
M5S63_RS21050 (4348365) 4348365..4348481 + 117 Protein_4119 VOC family protein -
M5S63_RS21055 (4348726) 4348726..4349847 + 1122 WP_000010829.1 M42 family metallopeptidase -
M5S63_RS21060 (4349844) 4349844..4350122 + 279 WP_000722973.1 PTS sugar transporter subunit IIB SgcB -
M5S63_RS21065 (4350134) 4350134..4351447 + 1314 WP_000460843.1 PTS sugar transporter subunit IIC SgcC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimB 4338818..4355362 16544


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T255308 WP_001054376.1 NZ_CP103521:4346324-4346581 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT255308 WP_001309181.1 NZ_CP103521:4346593-4347138 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References