255305

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3739736..3740354 Replicon chromosome
Accession NZ_CP103521
Organism Escherichia coli strain 2779 - blood draw same patient as MB9267

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag M5S63_RS18180 Protein ID WP_001291435.1
Coordinates 3740136..3740354 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag M5S63_RS18175 Protein ID WP_000344800.1
Coordinates 3739736..3740110 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5S63_RS18165 (3734825) 3734825..3736018 + 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
M5S63_RS18170 (3736041) 3736041..3739190 + 3150 WP_001132480.1 efflux RND transporter permease AcrB -
M5S63_RS18175 (3739736) 3739736..3740110 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
M5S63_RS18180 (3740136) 3740136..3740354 + 219 WP_001291435.1 HHA domain-containing protein Toxin
M5S63_RS18185 (3740526) 3740526..3741077 + 552 WP_001522034.1 maltose O-acetyltransferase -
M5S63_RS18190 (3741193) 3741193..3741663 + 471 WP_001490888.1 YlaC family protein -
M5S63_RS18195 (3741827) 3741827..3743377 + 1551 WP_001577872.1 cyclic-guanylate-specific phosphodiesterase PdeB -
M5S63_RS18200 (3743419) 3743419..3743772 - 354 WP_000878140.1 DUF1428 domain-containing protein -
M5S63_RS18210 (3744151) 3744151..3744462 + 312 WP_000409911.1 MGMT family protein -
M5S63_RS18215 (3744493) 3744493..3745065 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T255305 WP_001291435.1 NZ_CP103521:3740136-3740354 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT255305 WP_000344800.1 NZ_CP103521:3739736-3740110 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References