255304

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH_XRE
Location 3318049..3318754 Replicon chromosome
Accession NZ_CP103521
Organism Escherichia coli strain 2779 - blood draw same patient as MB9267

Toxin (Protein)


Gene name relE Uniprot ID S1F406
Locus tag M5S63_RS16325 Protein ID WP_000539521.1
Coordinates 3318049..3318435 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag M5S63_RS16330 Protein ID WP_001280945.1
Coordinates 3318425..3318754 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5S63_RS16305 (3314053) 3314053..3314679 + 627 WP_020233670.1 glutathione S-transferase GstB -
M5S63_RS16310 (3314676) 3314676..3315791 - 1116 WP_000555050.1 aldose sugar dehydrogenase YliI -
M5S63_RS16315 (3315902) 3315902..3316285 - 384 WP_000497137.1 biofilm formation regulator BssR -
M5S63_RS16320 (3316498) 3316498..3317823 + 1326 WP_000049367.1 30S ribosomal protein S12 methylthiotransferase RimO -
M5S63_RS16325 (3318049) 3318049..3318435 + 387 WP_000539521.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M5S63_RS16330 (3318425) 3318425..3318754 + 330 WP_001280945.1 DNA-binding transcriptional regulator Antitoxin
M5S63_RS16335 (3318824) 3318824..3320152 - 1329 WP_000086873.1 GGDEF domain-containing protein -
M5S63_RS16340 (3320160) 3320160..3322508 - 2349 WP_021523051.1 EAL domain-containing protein -
M5S63_RS16345 (3322686) 3322686..3323597 - 912 WP_001236019.1 glutathione ABC transporter permease GsiD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-94)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14293.45 Da        Isoelectric Point: 9.9296

>T255304 WP_000539521.1 NZ_CP103521:3318049-3318435 [Escherichia coli]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGTKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Download         Length: 387 bp

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11982.08 Da        Isoelectric Point: 10.0101

>AT255304 WP_001280945.1 NZ_CP103521:3318425-3318754 [Escherichia coli]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Download         Length: 330 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829GCT6

Antitoxin

Source ID Structure

References