Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2488551..2489512 Replicon chromosome
Accession NZ_CP103521
Organism Escherichia coli strain 2779 - blood draw same patient as MB9267

Toxin (Protein)


Gene name hipA Uniprot ID A0A1Q5ZNB7
Locus tag M5S63_RS12160 Protein ID WP_021523084.1
Coordinates 2488817..2489512 (+) Length 232 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag M5S63_RS12155 Protein ID WP_001296726.1
Coordinates 2488551..2488817 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5S63_RS12155 (2488551) 2488551..2488817 + 267 WP_001296726.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
M5S63_RS12160 (2488817) 2488817..2489512 + 696 WP_021523084.1 HipA N-terminal domain-containing protein Toxin
M5S63_RS12165 (2489712) 2489712..2491064 - 1353 WP_001551127.1 SIR2 family protein -
M5S63_RS12170 (2491279) 2491279..2492311 - 1033 Protein_2382 ISNCY family transposase -
M5S63_RS12175 (2492678) 2492678..2493577 - 900 WP_001523294.1 LysR family transcriptional regulator -
M5S63_RS12180 (2493716) 2493716..2494024 + 309 WP_001221046.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2491279..2492097 818


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-69)


Sequences

Toxin        


Download         Length: 232 a.a.        Molecular weight: 25773.79 Da        Isoelectric Point: 9.9928

>T255301 WP_021523084.1 NZ_CP103521:2488817-2489512 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLANRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLIPEDETIQAGGSYRLTPFYDIISAFPVLGGAGIHISDLKLAMGVNASKGKKTAIDKI
YPRHFLATAKVLKFPEVQMHEILSDFARMIPAALDNVKTSLPTDFPENVVTAVETNVLRLHGRLSREYGIK

Download         Length: 696 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10047.39 Da        Isoelectric Point: 4.9632

>AT255301 WP_001296726.1 NZ_CP103521:2488551-2488817 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDTKNASPES
TEQQDLEW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Q5ZNB7

Antitoxin

Source ID Structure

References