25528

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 1799213..1799826 Replicon chromosome
Accession NC_015848
Organism Mycobacterium canettii CIPT 140010059

Toxin (Protein)


Gene name vapC Uniprot ID G0TJE4
Locus tag MCAN_RS08315 Protein ID WP_014000826.1
Coordinates 1799422..1799826 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0E8UJ46
Locus tag MCAN_RS08310 Protein ID WP_009935474.1
Coordinates 1799213..1799416 (+) Length 68 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MCAN_RS08295 1794477..1797380 + 2904 WP_014000824.1 MMPL family transporter -
MCAN_RS08300 1797390..1797836 + 447 WP_014000825.1 F420H(2)-dependent quinone reductase -
MCAN_RS08305 1797871..1799160 + 1290 WP_003407781.1 threonine ammonia-lyase -
MCAN_RS08310 1799213..1799416 + 204 WP_009935474.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
MCAN_RS08315 1799422..1799826 + 405 WP_014000826.1 type II toxin-antitoxin system toxin ribonuclease VapC11 Toxin
MCAN_RS08320 1800016..1801350 + 1335 WP_014000151.1 ISL3-like element IS1557 family transposase -
MCAN_RS08325 1801340..1803043 - 1704 WP_014000827.1 malto-oligosyltrehalose trehalohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1800016..1801350 1334


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(2-44)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 14623.74 Da        Isoelectric Point: 5.6587

>T25528 WP_014000826.1 NC_015848:1799422-1799826 [Mycobacterium canettii CIPT 140010059]
MILIDTSAWVEYFRATGSIAAVEVRRLLSEEAARIAMCEPIAMEILSGALDDNTHTTLERLVNGLPSLNVDDAIDFRAAA
GIYRAARRAGETVRSINDCLIAALAIRHGARIVHRDADFDVIARITSLQAASFR

Download         Length: 405 bp

>T25528 NC_015848:1799422-1799826 [Mycobacterium canettii CIPT 140010059]
ATGATCCTCATCGACACATCGGCCTGGGTGGAGTACTTCCGTGCCACCGGATCAATCGCCGCTGTCGAAGTACGCCGGCT
GCTGTCCGAAGAAGCAGCGCGAATCGCTATGTGTGAGCCCATTGCGATGGAAATCTTGAGTGGCGCGCTCGACGACAACA
CCCACACGACGCTAGAGCGGCTCGTGAATGGCTTGCCGTCGTTGAACGTTGATGACGCGATTGACTTTCGTGCTGCCGCG
GGTATCTATCGCGCCGCCCGGCGCGCCGGCGAAACGGTTCGAAGCATCAACGACTGCCTCATAGCGGCGCTCGCGATCCG
CCACGGTGCGCGTATCGTCCACCGTGACGCCGACTTTGATGTGATTGCCCGGATTACCAGCCTGCAGGCCGCATCGTTTC
GGTGA

Antitoxin


Download         Length: 68 a.a.        Molecular weight: 7501.48 Da        Isoelectric Point: 4.3951

>AT25528 WP_009935474.1 NC_015848:1799213-1799416 [Mycobacterium canettii CIPT 140010059]
MSRTNIDIDDELAAEVMRRFGLTTKRAAVDLALRRLVGSPLSREFLLGLEGVGWEGDLDDLRSDRPD

Download         Length: 204 bp

>AT25528 NC_015848:1799213-1799416 [Mycobacterium canettii CIPT 140010059]
ATGTCGCGCACCAACATCGACATCGATGACGAACTTGCCGCCGAGGTCATGCGCAGGTTCGGGCTGACCACCAAGAGGGC
GGCGGTCGACCTTGCCCTACGACGGTTGGTCGGGTCGCCGTTGAGCCGTGAGTTTCTGCTCGGGCTGGAAGGCGTCGGCT
GGGAAGGCGACCTGGATGACTTGCGAAGCGATCGCCCAGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TJE4

Antitoxin

Source ID Structure
AlphaFold DB A0A0E8UJ46

References