Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3477013..3477631 Replicon chromosome
Accession NZ_CP103515
Organism Escherichia coli strain 5444

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag M5S96_RS17070 Protein ID WP_001291435.1
Coordinates 3477413..3477631 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag M5S96_RS17065 Protein ID WP_000344800.1
Coordinates 3477013..3477387 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5S96_RS17055 (3472102) 3472102..3473295 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
M5S96_RS17060 (3473318) 3473318..3476467 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
M5S96_RS17065 (3477013) 3477013..3477387 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
M5S96_RS17070 (3477413) 3477413..3477631 + 219 WP_001291435.1 HHA domain-containing protein Toxin
M5S96_RS17075 (3477803) 3477803..3478354 + 552 WP_000102564.1 maltose O-acetyltransferase -
M5S96_RS17080 (3478470) 3478470..3478940 + 471 WP_000136192.1 YlaC family protein -
M5S96_RS17085 (3479104) 3479104..3480654 + 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
M5S96_RS17090 (3480696) 3480696..3481049 - 354 WP_000878140.1 DUF1428 domain-containing protein -
M5S96_RS17100 (3481428) 3481428..3481739 + 312 WP_000409911.1 MGMT family protein -
M5S96_RS17105 (3481770) 3481770..3482342 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T255274 WP_001291435.1 NZ_CP103515:3477413-3477631 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT255274 WP_000344800.1 NZ_CP103515:3477013-3477387 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References