Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 5382118..5382743 Replicon chromosome
Accession NZ_CP103512
Organism Klebsiella pneumoniae strain 5531

Toxin (Protein)


Gene name vapC Uniprot ID A0A330XB05
Locus tag M5S57_RS25990 Protein ID WP_012737091.1
Coordinates 5382118..5382501 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag M5S57_RS25995 Protein ID WP_004150355.1
Coordinates 5382501..5382743 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5S57_RS25975 (5379484) 5379484..5380386 + 903 WP_002882822.1 formate dehydrogenase subunit beta -
M5S57_RS25980 (5380383) 5380383..5381018 + 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
M5S57_RS25985 (5381015) 5381015..5381944 + 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
M5S57_RS25990 (5382118) 5382118..5382501 - 384 WP_012737091.1 type II toxin-antitoxin system VapC family toxin Toxin
M5S57_RS25995 (5382501) 5382501..5382743 - 243 WP_004150355.1 CopG family transcriptional regulator Antitoxin
M5S57_RS26000 (5382948) 5382948..5383865 + 918 WP_012737090.1 alpha/beta hydrolase -
M5S57_RS26005 (5383879) 5383879..5384820 - 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
M5S57_RS26010 (5384865) 5384865..5385302 - 438 WP_002882809.1 D-aminoacyl-tRNA deacylase -
M5S57_RS26015 (5385299) 5385299..5386159 - 861 WP_004146232.1 virulence factor BrkB family protein -
M5S57_RS26020 (5386153) 5386153..5386752 - 600 WP_004151865.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-110)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14266.53 Da        Isoelectric Point: 7.2771

>T255256 WP_012737091.1 NZ_CP103512:c5382501-5382118 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRCEAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKGFAGIPGVVTPYEIHPE

Download         Length: 384 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT255256 WP_004150355.1 NZ_CP103512:c5382743-5382501 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A330XB05

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References