Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4912192..4912708 Replicon chromosome
Accession NZ_CP103512
Organism Klebsiella pneumoniae strain 5531

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag M5S57_RS23745 Protein ID WP_004178374.1
Coordinates 4912192..4912476 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag M5S57_RS23750 Protein ID WP_002886901.1
Coordinates 4912466..4912708 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5S57_RS23720 (4907588) 4907588..4907851 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
M5S57_RS23725 (4907981) 4907981..4908154 + 174 WP_041169004.1 hypothetical protein -
M5S57_RS23730 (4908157) 4908157..4908900 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
M5S57_RS23735 (4909257) 4909257..4911395 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
M5S57_RS23740 (4911724) 4911724..4912188 + 465 WP_004222151.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
M5S57_RS23745 (4912192) 4912192..4912476 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M5S57_RS23750 (4912466) 4912466..4912708 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
M5S57_RS23755 (4912786) 4912786..4914696 - 1911 WP_012737231.1 PRD domain-containing protein -
M5S57_RS23760 (4914719) 4914719..4915873 - 1155 WP_012737230.1 lactonase family protein -
M5S57_RS23765 (4915940) 4915940..4916680 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T255255 WP_004178374.1 NZ_CP103512:c4912476-4912192 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT255255 WP_002886901.1 NZ_CP103512:c4912708-4912466 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References