Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4339215..4339810 Replicon chromosome
Accession NZ_CP103508
Organism Escherichia coli O25b:H4-ST131 strain 5506

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag M5T03_RS21370 Protein ID WP_000239579.1
Coordinates 4339215..4339565 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag M5T03_RS21375 Protein ID WP_001223208.1
Coordinates 4339559..4339810 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T03_RS21350 (4334661) 4334661..4335683 - 1023 WP_001296689.1 ABC transporter permease -
M5T03_RS21355 (4335697) 4335697..4337199 - 1503 WP_000205813.1 sugar ABC transporter ATP-binding protein -
M5T03_RS21360 (4337339) 4337339..4338295 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
M5T03_RS21365 (4338605) 4338605..4339135 + 531 WP_000055075.1 inorganic diphosphatase -
M5T03_RS21370 (4339215) 4339215..4339565 - 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
M5T03_RS21375 (4339559) 4339559..4339810 - 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
M5T03_RS21380 (4340022) 4340022..4340363 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
M5T03_RS21385 (4340366) 4340366..4344145 - 3780 WP_000060945.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T255233 WP_000239579.1 NZ_CP103508:c4339565-4339215 [Escherichia coli O25b:H4-ST131]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT255233 WP_001223208.1 NZ_CP103508:c4339810-4339559 [Escherichia coli O25b:H4-ST131]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References