Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3597856..3598474 Replicon chromosome
Accession NZ_CP103508
Organism Escherichia coli O25b:H4-ST131 strain 5506

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag M5T03_RS17795 Protein ID WP_001291435.1
Coordinates 3598256..3598474 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag M5T03_RS17790 Protein ID WP_000344800.1
Coordinates 3597856..3598230 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T03_RS17780 (3592945) 3592945..3594138 + 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
M5T03_RS17785 (3594161) 3594161..3597310 + 3150 WP_001132478.1 efflux RND transporter permease AcrB -
M5T03_RS17790 (3597856) 3597856..3598230 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
M5T03_RS17795 (3598256) 3598256..3598474 + 219 WP_001291435.1 HHA domain-containing protein Toxin
M5T03_RS17800 (3598648) 3598648..3599199 + 552 WP_000102539.1 maltose O-acetyltransferase -
M5T03_RS17805 (3599315) 3599315..3599785 + 471 WP_259425935.1 YlaC family protein -
M5T03_RS17810 (3599949) 3599949..3601499 + 1551 WP_001385227.1 cyclic-guanylate-specific phosphodiesterase PdeB -
M5T03_RS17815 (3601541) 3601541..3601894 - 354 WP_000878135.1 DUF1428 family protein -
M5T03_RS17825 (3602273) 3602273..3602584 + 312 WP_000409908.1 MGMT family protein -
M5T03_RS17830 (3602615) 3602615..3603187 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T255228 WP_001291435.1 NZ_CP103508:3598256-3598474 [Escherichia coli O25b:H4-ST131]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT255228 WP_000344800.1 NZ_CP103508:3597856-3598230 [Escherichia coli O25b:H4-ST131]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References