Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 928242..928896 Replicon chromosome
Accession NZ_CP103508
Organism Escherichia coli O25b:H4-ST131 strain 5506

Toxin (Protein)


Gene name cptA Uniprot ID F4T2L4
Locus tag M5T03_RS04630 Protein ID WP_000244765.1
Coordinates 928489..928896 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID F4T2L5
Locus tag M5T03_RS04625 Protein ID WP_000354050.1
Coordinates 928242..928508 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T03_RS04605 (924330) 924330..925763 - 1434 WP_001296350.1 6-phospho-beta-glucosidase BglA -
M5T03_RS04610 (925808) 925808..926119 + 312 WP_001182956.1 N(4)-acetylcytidine aminohydrolase -
M5T03_RS04615 (926283) 926283..926942 + 660 WP_000250275.1 hemolysin III family protein -
M5T03_RS04620 (927019) 927019..927999 - 981 WP_000886084.1 tRNA-modifying protein YgfZ -
M5T03_RS04625 (928242) 928242..928508 + 267 WP_000354050.1 FAD assembly factor SdhE Antitoxin
M5T03_RS04630 (928489) 928489..928896 + 408 WP_000244765.1 protein YgfX Toxin
M5T03_RS04635 (928936) 928936..929457 - 522 WP_001055874.1 flavodoxin FldB -
M5T03_RS04640 (929569) 929569..930465 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
M5T03_RS04645 (930490) 930490..931200 + 711 WP_000715230.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
M5T03_RS04650 (931206) 931206..932939 + 1734 WP_000813195.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16043.95 Da        Isoelectric Point: 11.5202

>T255219 WP_000244765.1 NZ_CP103508:928489-928896 [Escherichia coli O25b:H4-ST131]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLIPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10535.07 Da        Isoelectric Point: 5.1599

>AT255219 WP_000354050.1 NZ_CP103508:928242-928508 [Escherichia coli O25b:H4-ST131]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRTFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A454A7D7

Antitoxin

Source ID Structure
AlphaFold DB A0A061L3F4

References