Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 10347..10906 Replicon plasmid pMB9481_2
Accession NZ_CP103505
Organism Klebsiella pneumoniae strain 5547

Toxin (Protein)


Gene name relE Uniprot ID S1PMX5
Locus tag M5R16_RS27480 Protein ID WP_000421257.1
Coordinates 10347..10622 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A5I3EQ05
Locus tag M5R16_RS27485 Protein ID WP_001674495.1
Coordinates 10622..10906 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5R16_RS27450 (6024) 6024..6338 - 315 WP_001302628.1 hypothetical protein -
M5R16_RS27455 (6908) 6908..7165 + 258 WP_094308825.1 hypothetical protein -
M5R16_RS27460 (7165) 7165..7755 + 591 WP_102000831.1 hypothetical protein -
M5R16_RS27465 (7967) 7967..9019 + 1053 WP_000655519.1 hypothetical protein -
M5R16_RS27470 (9195) 9195..9797 + 603 WP_094308828.1 ProQ/FINO family protein -
M5R16_RS27475 (9853) 9853..10092 + 240 Protein_14 hypothetical protein -
M5R16_RS27480 (10347) 10347..10622 - 276 WP_000421257.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M5R16_RS27485 (10622) 10622..10906 - 285 WP_001674495.1 ribbon-helix-helix domain-containing protein Antitoxin
M5R16_RS27490 (11811) 11811..12842 - 1032 WP_000907867.1 plasmid replication initiator RepA -
M5R16_RS27495 (13798) 13798..14076 + 279 WP_219065241.1 ash family protein -
M5R16_RS27500 (13994) 13994..14281 + 288 WP_000074849.1 conjugal transfer protein TraA -
M5R16_RS27505 (14723) 14723..15256 + 534 WP_001306770.1 transcription termination/antitermination NusG family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..87513 87513


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(14-51)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10749.45 Da        Isoelectric Point: 9.9324

>T255210 WP_000421257.1 NZ_CP103505:c10622-10347 [Klebsiella pneumoniae]
MELKWTSKALSDLARLYDFLVLASKPAAARTVQSLTQAPVILLTHPRMGEQLFQFEPREVRRIFAGEYEIRYELNGQTIY
VLRLWHTRENR

Download         Length: 276 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10460.87 Da        Isoelectric Point: 5.6558

>AT255210 WP_001674495.1 NZ_CP103505:c10906-10622 [Klebsiella pneumoniae]
MQMKNNSAQATKVITAHVPLPMADKVDQMAARLERSRGWVIKQALSAWLAQEEERNRLTLEALDDVTSGQVIDHQAVQAW
ADSLSTDNPLPVPR

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PMX5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I3EQ05

References