Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /RES-TIGR02293 |
| Location | 149236..150146 | Replicon | plasmid pMB9481_1 |
| Accession | NZ_CP103504 | ||
| Organism | Klebsiella pneumoniae strain 5547 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | A0A5Q9LR54 |
| Locus tag | M5R16_RS26915 | Protein ID | WP_004181896.1 |
| Coordinates | 149236..149706 (-) | Length | 157 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | A0A2J4RLY9 |
| Locus tag | M5R16_RS26920 | Protein ID | WP_004181895.1 |
| Coordinates | 149703..150146 (-) | Length | 148 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| M5R16_RS26895 (M5R16_26895) | 145833..146210 | + | 378 | WP_004181901.1 | hypothetical protein | - |
| M5R16_RS26900 (M5R16_26900) | 146408..147382 | - | 975 | WP_043907013.1 | hypothetical protein | - |
| M5R16_RS26905 (M5R16_26905) | 147985..148143 | - | 159 | WP_004181898.1 | type I toxin-antitoxin system Hok family toxin | - |
| M5R16_RS26910 (M5R16_26910) | 148866..149126 | + | 261 | WP_004026352.1 | hypothetical protein | - |
| M5R16_RS26915 (M5R16_26915) | 149236..149706 | - | 471 | WP_004181896.1 | RES family NAD+ phosphorylase | Toxin |
| M5R16_RS26920 (M5R16_26920) | 149703..150146 | - | 444 | WP_004181895.1 | DUF2384 domain-containing protein | Antitoxin |
| M5R16_RS26925 (M5R16_26925) | 150247..151518 | - | 1272 | WP_004181894.1 | translesion error-prone DNA polymerase V subunit UmuC | - |
| M5R16_RS26930 (M5R16_26930) | 151518..151940 | - | 423 | WP_004181893.1 | translesion error-prone DNA polymerase V autoproteolytic subunit | - |
| M5R16_RS26935 (M5R16_26935) | 152026..153513 | - | 1488 | WP_004178082.1 | group II intron reverse transcriptase/maturase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | blaNDM-1 / mph(E) / msr(E) / armA / sul1 / qacE / aadA2 / dfrA12 | - | 1..235473 | 235473 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 157 a.a. Molecular weight: 17549.81 Da Isoelectric Point: 4.6155
>T255208 WP_004181896.1 NZ_CP103504:c149706-149236 [Klebsiella pneumoniae]
VIFYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK
VIFYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK
Download Length: 471 bp
Antitoxin
Download Length: 148 a.a. Molecular weight: 16536.87 Da Isoelectric Point: 10.3013
>AT255208 WP_004181895.1 NZ_CP103504:c150146-149703 [Klebsiella pneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVVNRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDREAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVVNRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDREAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS
Download Length: 444 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A5Q9LR54 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2J4RLY9 |