255207

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 22789..23311 Replicon plasmid pMB9481_1
Accession NZ_CP103504
Organism Klebsiella pneumoniae strain 5547

Toxin (Protein)


Gene name stbE Uniprot ID A0A0C7KG00
Locus tag M5R16_RS26295 Protein ID WP_038991638.1
Coordinates 23027..23311 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID A0A2J4R0U8
Locus tag M5R16_RS26290 Protein ID WP_004181777.1
Coordinates 22789..23037 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5R16_RS26270 (M5R16_26270) 17998..18819 - 822 WP_004181772.1 hypothetical protein -
M5R16_RS26275 (M5R16_26275) 18881..19234 - 354 WP_004181774.1 hypothetical protein -
M5R16_RS26280 (M5R16_26280) 19379..20365 - 987 WP_040120328.1 hypothetical protein -
M5R16_RS26285 (M5R16_26285) 20699..22498 - 1800 WP_043907032.1 ATP-dependent helicase -
M5R16_RS26290 (M5R16_26290) 22789..23037 + 249 WP_004181777.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
M5R16_RS26295 (M5R16_26295) 23027..23311 + 285 WP_038991638.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M5R16_RS26300 (M5R16_26300) 23328..23429 - 102 Protein_27 IS200/IS605 family transposase -
M5R16_RS26305 (M5R16_26305) 23465..24691 + 1227 WP_040120327.1 RNA-guided endonuclease TnpB family protein -
M5R16_RS26310 (M5R16_26310) 24963..25187 - 225 Protein_29 transposase -
M5R16_RS26315 (M5R16_26315) 25266..25694 - 429 WP_077256229.1 IS200/IS605 family transposase -
M5R16_RS26320 (M5R16_26320) 25730..26917 + 1188 WP_043907031.1 RNA-guided endonuclease TnpB family protein -
M5R16_RS26325 (M5R16_26325) 26962..27333 - 372 WP_044816264.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid blaNDM-1 / mph(E) / msr(E) / armA / sul1 / qacE / aadA2 / dfrA12 - 1..235473 235473


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10993.73 Da        Isoelectric Point: 10.6516

>T255207 WP_038991638.1 NZ_CP103504:23027-23311 [Klebsiella pneumoniae]
MTYKLAFNESALKEWKKLGHTIREQFKKKLAERLLNPRVPASQLHGRKDQYKIKLRGAGYRLVYSVNDDVVTVTVIGVGK
RENDDIYHLTKHRN

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8925.17 Da        Isoelectric Point: 3.8209

>AT255207 WP_004181777.1 NZ_CP103504:22789-23037 [Klebsiella pneumoniae]
MAFQVLTTTAASITELKRDPMGTFNAGEGAPVAILNRNEPAFYCVPPALYAQLMELLEDQELGRIADERIGEAVIEVSLD
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0C7KG00

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4R0U8

References