Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/LOTUS_5_Limkain_b1(toxin) |
Location | 5258662..5259287 | Replicon | chromosome |
Accession | NZ_CP103503 | ||
Organism | Klebsiella pneumoniae strain 5547 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | R4Y4A3 |
Locus tag | M5R16_RS25720 | Protein ID | WP_002882817.1 |
Coordinates | 5258662..5259045 (-) | Length | 128 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | J2DFR0 |
Locus tag | M5R16_RS25725 | Protein ID | WP_004150355.1 |
Coordinates | 5259045..5259287 (-) | Length | 81 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
M5R16_RS25705 (5256028) | 5256028..5256930 | + | 903 | WP_002882822.1 | formate dehydrogenase subunit beta | - |
M5R16_RS25710 (5256927) | 5256927..5257562 | + | 636 | WP_002882818.1 | formate dehydrogenase cytochrome b556 subunit | - |
M5R16_RS25715 (5257559) | 5257559..5258488 | + | 930 | WP_004150358.1 | formate dehydrogenase accessory protein FdhE | - |
M5R16_RS25720 (5258662) | 5258662..5259045 | - | 384 | WP_002882817.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
M5R16_RS25725 (5259045) | 5259045..5259287 | - | 243 | WP_004150355.1 | CopG family transcriptional regulator | Antitoxin |
M5R16_RS25730 (5259492) | 5259492..5260409 | + | 918 | WP_004181612.1 | alpha/beta hydrolase | - |
M5R16_RS25735 (5260423) | 5260423..5261364 | - | 942 | WP_004178031.1 | fatty acid biosynthesis protein FabY | - |
M5R16_RS25740 (5261409) | 5261409..5261846 | - | 438 | WP_002882809.1 | D-aminoacyl-tRNA deacylase | - |
M5R16_RS25745 (5261843) | 5261843..5262703 | - | 861 | WP_004146232.1 | virulence factor BrkB family protein | - |
M5R16_RS25750 (5262697) | 5262697..5263296 | - | 600 | WP_004151865.1 | glucose-1-phosphatase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 128 a.a. Molecular weight: 14377.62 Da Isoelectric Point: 7.3178
>T255206 WP_002882817.1 NZ_CP103503:c5259045-5258662 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE
Download Length: 384 bp
Antitoxin
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H3GPK8 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H3GGU9 |