Detailed information of TA system TA255205

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 4944704..4946385
• Replicon: chromosome
• Accession: NZ_CP103503
• Organism: Klebsiella pneumoniae strain 5547

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: -
• Locus tag: M5R16_RS24280
• Protein ID: WP_004178299.1
• Coordinates: 4944704..4945621 (-)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: A6TH05
• Locus tag: M5R16_RS24285
• Protein ID: WP_004177809.1
• Coordinates: 4945627..4946385 (-)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M5R16_RS24260 (4940010)	4940010..4941530	+	1521	WP_002885173.1	sugar ABC transporter ATP-binding protein	-
M5R16_RS24265 (4941527)	4941527..4942525	+	999	WP_002885172.1	ribose ABC transporter permease	-
M5R16_RS24270 (4942556)	4942556..4943497	+	942	WP_002885156.1	ABC transporter substrate-binding protein	-
M5R16_RS24275 (4943572)	4943572..4944579	+	1008	WP_004178300.1	carbohydrate kinase family protein	-
M5R16_RS24280 (4944704)	4944704..4945621	-	918	WP_004178299.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
M5R16_RS24285 (4945627)	4945627..4946385	-	759	WP_004177809.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
M5R16_RS24290 (4946471)	4946471..4947199	-	729	WP_004178298.1	response regulator transcription factor	-
M5R16_RS24295 (4947472)	4947472..4949619	+	2148	WP_012737173.1	formate dehydrogenase H subunit alpha, selenocysteine-containing	-
M5R16_RS24300 (4949849)	4949849..4950535	+	687	WP_004151733.1	tetratricopeptide repeat protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-93)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34649.06 Da
• Isoelectric Point: 5.4707

>T255205 WP_004178299.1 NZ_CP103503:c4945621-4944704 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPSQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 918 bp

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28548.92 Da
• Isoelectric Point: 10.0870

>AT255205 WP_004177809.1 NZ_CP103503:c4946385-4945627 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

Structures

Antitoxin

• AlphaFold DB: A6TH05