Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4789009..4789525 Replicon chromosome
Accession NZ_CP103503
Organism Klebsiella pneumoniae strain 5547

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag M5R16_RS23485 Protein ID WP_004178374.1
Coordinates 4789009..4789293 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag M5R16_RS23490 Protein ID WP_002886901.1
Coordinates 4789283..4789525 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5R16_RS23460 (4784493) 4784493..4784756 - 264 WP_228985702.1 PTS sugar transporter subunit IIB -
M5R16_RS23465 (4784886) 4784886..4785059 + 174 WP_032408826.1 hypothetical protein -
M5R16_RS23470 (4785062) 4785062..4785805 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
M5R16_RS23475 (4786162) 4786162..4788300 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
M5R16_RS23480 (4788541) 4788541..4789005 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
M5R16_RS23485 (4789009) 4789009..4789293 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M5R16_RS23490 (4789283) 4789283..4789525 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
M5R16_RS23495 (4789603) 4789603..4791513 - 1911 WP_004178373.1 PRD domain-containing protein -
M5R16_RS23500 (4791536) 4791536..4792690 - 1155 WP_004178372.1 lactonase family protein -
M5R16_RS23505 (4792757) 4792757..4793497 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T255204 WP_004178374.1 NZ_CP103503:c4789293-4789009 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT255204 WP_002886901.1 NZ_CP103503:c4789525-4789283 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References