Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2620629..2622217 Replicon chromosome
Accession NZ_CP103503
Organism Klebsiella pneumoniae strain 5547

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag M5R16_RS13130 Protein ID WP_004179815.1
Coordinates 2620895..2622217 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag M5R16_RS13125 Protein ID WP_004176198.1
Coordinates 2620629..2620895 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5R16_RS13100 (2615779) 2615779..2616702 + 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -
M5R16_RS13105 (2616683) 2616683..2617837 - 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
M5R16_RS13110 (2618183) 2618183..2619562 + 1380 WP_004179808.1 nucleobase:cation symporter-2 family protein -
M5R16_RS13115 (2619540) 2619540..2620040 + 501 WP_004179811.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
M5R16_RS13120 (2620037) 2620037..2620363 + 327 WP_002904788.1 hydroxyisourate hydrolase -
M5R16_RS13125 (2620629) 2620629..2620895 + 267 WP_004176198.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
M5R16_RS13130 (2620895) 2620895..2622217 + 1323 WP_004179815.1 type II toxin-antitoxin system HipA family toxin Toxin
M5R16_RS13135 (2622234) 2622234..2623526 - 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
M5R16_RS13140 (2623668) 2623668..2624672 - 1005 WP_004179822.1 fimbrial protein -
M5R16_RS13145 (2624660) 2624660..2627161 - 2502 WP_004179823.1 fimbria/pilus outer membrane usher protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - iroE / mgtC 2585794..2829391 243597


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49152.42 Da        Isoelectric Point: 7.2850

>T255201 WP_004179815.1 NZ_CP103503:2620895-2622217 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTHQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9936.36 Da        Isoelectric Point: 8.5912

>AT255201 WP_004176198.1 NZ_CP103503:2620629-2620895 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References