Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 825654..826311 Replicon chromosome
Accession NZ_CP103503
Organism Klebsiella pneumoniae strain 5547

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag M5R16_RS04065 Protein ID WP_004181233.1
Coordinates 825901..826311 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag M5R16_RS04060 Protein ID WP_002916312.1
Coordinates 825654..825920 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5R16_RS04035 (820810) 820810..822243 - 1434 WP_004181234.1 6-phospho-beta-glucosidase -
M5R16_RS04040 (822362) 822362..823090 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
M5R16_RS04045 (823140) 823140..823451 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
M5R16_RS04050 (823615) 823615..824274 + 660 WP_002916317.1 hemolysin III family protein -
M5R16_RS04055 (824425) 824425..825408 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
M5R16_RS04060 (825654) 825654..825920 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
M5R16_RS04065 (825901) 825901..826311 + 411 WP_004181233.1 protein YgfX Toxin
M5R16_RS04070 (826318) 826318..826839 - 522 WP_004144730.1 flavodoxin FldB -
M5R16_RS04075 (826940) 826940..827836 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
M5R16_RS04080 (827859) 827859..828572 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
M5R16_RS04085 (828578) 828578..830311 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16121.92 Da        Isoelectric Point: 11.1565

>T255196 WP_004181233.1 NZ_CP103503:825901-826311 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAEEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT255196 WP_002916312.1 NZ_CP103503:825654-825920 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References