Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4789915..4790431 Replicon chromosome
Accession NZ_CP103499
Organism Klebsiella pneumoniae strain 5589

Toxin (Protein)


Gene name relE Uniprot ID A0A2A2BGN7
Locus tag M5S52_RS23435 Protein ID WP_009486548.1
Coordinates 4789915..4790199 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag M5S52_RS23440 Protein ID WP_002886901.1
Coordinates 4790189..4790431 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5S52_RS23410 (4785332) 4785332..4785595 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
M5S52_RS23415 (4785725) 4785725..4785898 + 174 WP_002886906.1 hypothetical protein -
M5S52_RS23420 (4785901) 4785901..4786644 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
M5S52_RS23425 (4787001) 4787001..4789139 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
M5S52_RS23430 (4789447) 4789447..4789911 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
M5S52_RS23435 (4789915) 4789915..4790199 - 285 WP_009486548.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M5S52_RS23440 (4790189) 4790189..4790431 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
M5S52_RS23445 (4790509) 4790509..4792419 - 1911 WP_009486549.1 PRD domain-containing protein -
M5S52_RS23450 (4792442) 4792442..4793596 - 1155 WP_020316350.1 lactonase family protein -
M5S52_RS23455 (4793663) 4793663..4794403 - 741 WP_009486551.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.4951

>T255189 WP_009486548.1 NZ_CP103499:c4790199-4789915 [Klebsiella pneumoniae]
MTYELEFDPRARREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT255189 WP_002886901.1 NZ_CP103499:c4790431-4790189 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A2BGN7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References