Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 828827..829484 Replicon chromosome
Accession NZ_CP103499
Organism Klebsiella pneumoniae strain 5589

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag M5S52_RS04120 Protein ID WP_002916310.1
Coordinates 829074..829484 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag M5S52_RS04115 Protein ID WP_002916312.1
Coordinates 828827..829093 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5S52_RS04090 (823983) 823983..825416 - 1434 WP_009485881.1 6-phospho-beta-glucosidase BglA -
M5S52_RS04095 (825535) 825535..826263 - 729 WP_009485882.1 MurR/RpiR family transcriptional regulator -
M5S52_RS04100 (826313) 826313..826624 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
M5S52_RS04105 (826788) 826788..827447 + 660 WP_002916317.1 hemolysin III family protein -
M5S52_RS04110 (827598) 827598..828581 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
M5S52_RS04115 (828827) 828827..829093 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
M5S52_RS04120 (829074) 829074..829484 + 411 WP_002916310.1 protein YgfX Toxin
M5S52_RS04125 (829491) 829491..830012 - 522 WP_002916308.1 flavodoxin FldB -
M5S52_RS04130 (830113) 830113..831009 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
M5S52_RS04135 (831032) 831032..831745 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
M5S52_RS04140 (831751) 831751..833484 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T255181 WP_002916310.1 NZ_CP103499:829074-829484 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT255181 WP_002916312.1 NZ_CP103499:828827-829093 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References