Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 37567..38093 Replicon plasmid pMB9539_2
Accession NZ_CP103496
Organism Enterobacter hormaechei strain 70

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag M5T15_RS23415 Protein ID WP_000323025.1
Coordinates 37806..38093 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID J5W3H0
Locus tag M5T15_RS23410 Protein ID WP_004196370.1
Coordinates 37567..37806 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T15_RS23375 (32904) 32904..33096 - 193 Protein_39 MFS transporter -
M5T15_RS23380 (33126) 33126..34103 + 978 WP_004196334.1 chromate resistance protein -
M5T15_RS23385 (34060) 34060..35436 + 1377 WP_259429925.1 chromate efflux transporter -
M5T15_RS23390 (35467) 35467..36156 - 690 WP_004196322.1 hypothetical protein -
M5T15_RS23395 (36170) 36170..36907 - 738 WP_008460272.1 HupE/UreJ family protein -
M5T15_RS23400 (36951) 36951..37316 - 366 WP_009651956.1 hypothetical protein -
M5T15_RS23405 (37444) 37444..37542 - 99 Protein_45 protein YdfV -
M5T15_RS23410 (37567) 37567..37806 + 240 WP_004196370.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
M5T15_RS23415 (37806) 37806..38093 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
M5T15_RS23420 (38165) 38165..38323 + 159 WP_013087178.1 type I toxin-antitoxin system Hok family toxin -
M5T15_RS23425 (39202) 39202..39516 + 315 WP_023338051.1 hypothetical protein -
M5T15_RS23430 (39576) 39576..40037 + 462 WP_048974901.1 DUF1419 domain-containing protein -
M5T15_RS23435 (40127) 40127..40327 + 201 WP_031494497.1 hypothetical protein -
M5T15_RS23440 (40368) 40368..41159 + 792 WP_032663722.1 N-6 DNA methylase -
M5T15_RS23445 (41202) 41202..41537 + 336 WP_023345479.1 hypothetical protein -
M5T15_RS23450 (42227) 42227..42520 + 294 WP_032663725.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..83861 83861


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(3-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T255179 WP_000323025.1 NZ_CP103496:37806-38093 [Enterobacter hormaechei]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9018.43 Da        Isoelectric Point: 4.3894

>AT255179 WP_004196370.1 NZ_CP103496:37567-37806 [Enterobacter hormaechei]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLCNPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4QRH4

References