Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 4643995..4644611 Replicon chromosome
Accession NZ_CP103494
Organism Enterobacter hormaechei strain 70

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag M5T15_RS22235 Protein ID WP_045142560.1
Coordinates 4643995..4644366 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A6G4MTK3
Locus tag M5T15_RS22240 Protein ID WP_015569912.1
Coordinates 4644369..4644611 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T15_RS22220 (M5T15_22220) 4641495..4642397 + 903 WP_014072386.1 formate dehydrogenase subunit beta -
M5T15_RS22225 (M5T15_22225) 4642394..4643029 + 636 WP_003861958.1 formate dehydrogenase cytochrome b556 subunit -
M5T15_RS22230 (M5T15_22230) 4643026..4643955 + 930 WP_045142561.1 formate dehydrogenase accessory protein FdhE -
M5T15_RS22235 (M5T15_22235) 4643995..4644366 - 372 WP_045142560.1 type II toxin-antitoxin system VapC family toxin Toxin
M5T15_RS22240 (M5T15_22240) 4644369..4644611 - 243 WP_015569912.1 ribbon-helix-helix domain-containing protein Antitoxin
M5T15_RS22245 (M5T15_22245) 4644810..4645730 + 921 WP_045142559.1 alpha/beta hydrolase -
M5T15_RS22250 (M5T15_22250) 4645739..4646680 - 942 WP_015569910.1 fatty acid biosynthesis protein FabY -
M5T15_RS22255 (M5T15_22255) 4646725..4647162 - 438 WP_015569909.1 D-aminoacyl-tRNA deacylase -
M5T15_RS22260 (M5T15_22260) 4647159..4648040 - 882 WP_003861949.1 virulence factor BrkB family protein -
M5T15_RS22265 (M5T15_22265) 4648034..4648633 - 600 WP_003861947.1 glucose-1-phosphatase -
M5T15_RS22270 (M5T15_22270) 4648752..4649552 - 801 WP_045142558.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-115)

Antitoxin

Ribbon-helix-helix protein, CopG

(12-49)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13716.82 Da        Isoelectric Point: 6.6419

>T255178 WP_045142560.1 NZ_CP103494:c4644366-4643995 [Enterobacter hormaechei]
MEHMAVFDTNILIDLFNNRVEAADAIEHTASHRAISLITWMEVMVGARRRGHEAKTAAVMGAFEIIDVSRDIAERSVSLR
EKHGMKLPDAIILATAQSRKCPLISRNTKDFAGIDEVLTPYQV

Download         Length: 372 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9440.72 Da        Isoelectric Point: 4.4076

>AT255178 WP_015569912.1 NZ_CP103494:c4644611-4644369 [Enterobacter hormaechei]
MSVLAELDMGRILIDLSDDVIQRLDNLKQLRNQPRAELLREAIELYLDQQSSSVIRNALGLWGDRKEDGLEYERKLREEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A6G4MTK3

References