Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3779916..3780573 Replicon chromosome
Accession NZ_CP103494
Organism Enterobacter hormaechei strain 70

Toxin (Protein)


Gene name cptA Uniprot ID A0A179PSF7
Locus tag M5T15_RS18050 Protein ID WP_017382887.1
Coordinates 3779916..3780326 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag M5T15_RS18055 Protein ID WP_003863437.1
Coordinates 3780307..3780573 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T15_RS18030 (M5T15_18030) 3775914..3777647 - 1734 WP_045141946.1 single-stranded-DNA-specific exonuclease RecJ -
M5T15_RS18035 (M5T15_18035) 3777653..3778366 - 714 WP_003863443.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
M5T15_RS18040 (M5T15_18040) 3778395..3779291 - 897 WP_259429675.1 site-specific tyrosine recombinase XerD -
M5T15_RS18045 (M5T15_18045) 3779393..3779914 + 522 WP_015571793.1 flavodoxin FldB -
M5T15_RS18050 (M5T15_18050) 3779916..3780326 - 411 WP_017382887.1 protein YgfX Toxin
M5T15_RS18055 (M5T15_18055) 3780307..3780573 - 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
M5T15_RS18060 (M5T15_18060) 3780868..3781848 + 981 WP_017382888.1 tRNA-modifying protein YgfZ -
M5T15_RS18065 (M5T15_18065) 3781960..3782619 - 660 WP_003863433.1 hemolysin III family protein -
M5T15_RS18070 (M5T15_18070) 3782886..3783617 + 732 WP_015571796.1 MurR/RpiR family transcriptional regulator -
M5T15_RS18075 (M5T15_18075) 3783734..3785167 + 1434 WP_017382891.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16321.21 Da        Isoelectric Point: 11.4775

>T255177 WP_017382887.1 NZ_CP103494:c3780326-3779916 [Enterobacter hormaechei]
VVLWQSDLRVSWRSQWMSLLLHGLVAALVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMMGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT255177 WP_003863437.1 NZ_CP103494:c3780573-3780307 [Enterobacter hormaechei]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A179PSF7

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References