Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2359485..2360224 Replicon chromosome
Accession NZ_CP103494
Organism Enterobacter hormaechei strain 70

Toxin (Protein)


Gene name tacT Uniprot ID A0A3L9PBP9
Locus tag M5T15_RS11400 Protein ID WP_003857133.1
Coordinates 2359485..2359970 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A837FCR9
Locus tag M5T15_RS11405 Protein ID WP_003857131.1
Coordinates 2359958..2360224 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T15_RS11365 (M5T15_11365) 2354762..2355520 - 759 WP_045142134.1 trans-aconitate 2-methyltransferase -
M5T15_RS11370 (M5T15_11370) 2355605..2356189 - 585 WP_045142135.1 GDP-mannose pyrophosphatase -
M5T15_RS11375 (M5T15_11375) 2356276..2357034 + 759 WP_045142136.1 DeoR/GlpR family DNA-binding transcription regulator -
M5T15_RS11380 (M5T15_11380) 2357139..2357459 + 321 WP_045142137.1 hypothetical protein -
M5T15_RS11385 (M5T15_11385) 2357479..2357622 + 144 WP_227789192.1 hypothetical protein -
M5T15_RS11390 (M5T15_11390) 2357884..2358849 + 966 WP_032648329.1 hypothetical protein -
M5T15_RS11395 (M5T15_11395) 2358865..2359434 + 570 WP_032648331.1 hypothetical protein -
M5T15_RS11400 (M5T15_11400) 2359485..2359970 - 486 WP_003857133.1 GNAT family N-acetyltransferase Toxin
M5T15_RS11405 (M5T15_11405) 2359958..2360224 - 267 WP_003857131.1 DUF1778 domain-containing protein Antitoxin
M5T15_RS11410 (M5T15_11410) 2360288..2361217 - 930 WP_045142163.1 LysR family transcriptional regulator -
M5T15_RS11415 (M5T15_11415) 2361347..2362735 + 1389 WP_045142139.1 MFS transporter -
M5T15_RS11420 (M5T15_11420) 2362757..2363752 - 996 WP_015570513.1 DUF2891 domain-containing protein -
M5T15_RS11425 (M5T15_11425) 2363762..2364748 - 987 WP_017382341.1 DUF979 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(58-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17540.23 Da        Isoelectric Point: 9.9658

>T255171 WP_003857133.1 NZ_CP103494:c2359970-2359485 [Enterobacter hormaechei]
VGRVTAPEPLSSVHQLAEFVSGEAVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTQATGNLRRNM
PDPIPVIILARLAVDVSLRGNGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.50 Da        Isoelectric Point: 4.3837

>AT255171 WP_003857131.1 NZ_CP103494:c2360224-2359958 [Enterobacter hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3L9PBP9

Antitoxin

Source ID Structure
AlphaFold DB A0A837FCR9

References