Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 1759807..1760604 Replicon chromosome
Accession NZ_CP103494
Organism Enterobacter hormaechei strain 70

Toxin (Protein)


Gene name KacT Uniprot ID -
Locus tag M5T15_RS08365 Protein ID WP_045141441.1
Coordinates 1760083..1760604 (+) Length 174 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID F5RT92
Locus tag M5T15_RS08360 Protein ID WP_001303459.1
Coordinates 1759807..1760076 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T15_RS08325 (M5T15_08325) 1755347..1755706 + 360 WP_017384779.1 helix-turn-helix domain-containing protein -
M5T15_RS08330 (M5T15_08330) 1755785..1755880 - 96 Protein_1616 transcriptional regulator -
M5T15_RS08335 (M5T15_08335) 1756033..1757274 + 1242 WP_017693667.1 bifunctional glucose-1-phosphatase/inositol phosphatase -
M5T15_RS08340 (M5T15_08340) 1757307..1757534 - 228 WP_006809324.1 YccJ family protein -
M5T15_RS08345 (M5T15_08345) 1757553..1758149 - 597 WP_006809323.1 NAD(P)H:quinone oxidoreductase -
M5T15_RS08350 (M5T15_08350) 1758541..1758711 + 171 WP_001273664.1 general stress protein -
M5T15_RS08355 (M5T15_08355) 1758828..1759733 + 906 WP_045141440.1 DMT family transporter -
M5T15_RS08360 (M5T15_08360) 1759807..1760076 + 270 WP_001303459.1 DUF1778 domain-containing protein Antitoxin
M5T15_RS08365 (M5T15_08365) 1760083..1760604 + 522 WP_045141441.1 GNAT family N-acetyltransferase Toxin
M5T15_RS08370 (M5T15_08370) 1760663..1761985 - 1323 WP_045141442.1 pyrimidine utilization transport protein G -
M5T15_RS08375 (M5T15_08375) 1762007..1762498 - 492 WP_045141443.1 pyrimidine utilization flavin reductase protein F -
M5T15_RS08380 (M5T15_08380) 1762511..1763101 - 591 WP_045141444.1 malonic semialdehyde reductase -
M5T15_RS08385 (M5T15_08385) 1763111..1763911 - 801 WP_039271149.1 pyrimidine utilization protein D -
M5T15_RS08390 (M5T15_08390) 1763919..1764305 - 387 WP_015570870.1 pyrimidine utilization protein C -
M5T15_RS08395 (M5T15_08395) 1764317..1765006 - 690 WP_045141445.1 pyrimidine utilization protein B -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-149)

Antitoxin

Vibrio phage ICP1, Orf50

(2-88)


Sequences

Toxin        


Download         Length: 174 a.a.        Molecular weight: 19407.16 Da        Isoelectric Point: 7.4318

>T255170 WP_045141441.1 NZ_CP103494:1760083-1760604 [Enterobacter hormaechei]
VANLTIEMLSEGTDYDFGDFDCGEPSLNAFLTEHLVRQHGGRILRGYLLKERDHPRVLGYYTLSGSCFEKAMLPSKTQQR
RIPYSNVPSVTLGRLAVHKELQGNEWGTALVTHAMRVVYLASQAVGVHGIFVDALNERAKRFYLKLGFIPLAGENSSSLF
FPTQSIERLFEQA

Download         Length: 522 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10248.70 Da        Isoelectric Point: 5.8836

>AT255170 WP_001303459.1 NZ_CP103494:1759807-1760076 [Enterobacter hormaechei]
MPALKKQRIDLRLSDEDKTMIEEAAAMTNQTITQFMVNSASERAAEVIEQHRRLVLNEASWNAVMDAIDNPPEPNERLKR
AAKRLRNME

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7D7BCZ2

References