Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1121874..1122494 Replicon chromosome
Accession NZ_CP103494
Organism Enterobacter hormaechei strain 70

Toxin (Protein)


Gene name Hha Uniprot ID A0A837FFM2
Locus tag M5T15_RS05305 Protein ID WP_015571250.1
Coordinates 1121874..1122092 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID F5RUW7
Locus tag M5T15_RS05310 Protein ID WP_006809850.1
Coordinates 1122120..1122494 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T15_RS05275 (M5T15_05275) 1117886..1118146 + 261 WP_015571255.1 type B 50S ribosomal protein L31 -
M5T15_RS05280 (M5T15_05280) 1118149..1118289 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
M5T15_RS05285 (M5T15_05285) 1118286..1118996 - 711 WP_032670463.1 GNAT family protein -
M5T15_RS05290 (M5T15_05290) 1119098..1120558 + 1461 WP_045142063.1 PLP-dependent aminotransferase family protein -
M5T15_RS05295 (M5T15_05295) 1120530..1120997 - 468 WP_015571252.1 YlaC family protein -
M5T15_RS05300 (M5T15_05300) 1121114..1121665 - 552 WP_015571251.1 maltose O-acetyltransferase -
M5T15_RS05305 (M5T15_05305) 1121874..1122092 - 219 WP_015571250.1 HHA domain-containing protein Toxin
M5T15_RS05310 (M5T15_05310) 1122120..1122494 - 375 WP_006809850.1 Hha toxicity modulator TomB Antitoxin
M5T15_RS05315 (M5T15_05315) 1123005..1126151 - 3147 WP_259429732.1 multidrug efflux RND transporter permease subunit AcrB -
M5T15_RS05320 (M5T15_05320) 1126174..1127367 - 1194 WP_017694395.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8583.95 Da        Isoelectric Point: 8.9008

>T255168 WP_015571250.1 NZ_CP103494:c1122092-1121874 [Enterobacter hormaechei]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14497.28 Da        Isoelectric Point: 4.8989

>AT255168 WP_006809850.1 NZ_CP103494:c1122494-1122120 [Enterobacter hormaechei]
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FFM2

Antitoxin

Source ID Structure
AlphaFold DB A0A837FGN8

References