Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 341938..342534 Replicon chromosome
Accession NZ_CP103494
Organism Enterobacter hormaechei strain 70

Toxin (Protein)


Gene name PumA Uniprot ID A0A7G3EX93
Locus tag M5T15_RS01635 Protein ID WP_015570164.1
Coordinates 342232..342534 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID A0A927HL08
Locus tag M5T15_RS01630 Protein ID WP_023295755.1
Coordinates 341938..342225 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T15_RS01625 (M5T15_01625) 340310..341941 + 1632 WP_003860350.1 Na/Pi cotransporter family protein -
M5T15_RS01630 (M5T15_01630) 341938..342225 - 288 WP_023295755.1 putative addiction module antidote protein Antitoxin
M5T15_RS01635 (M5T15_01635) 342232..342534 - 303 WP_015570164.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M5T15_RS01640 (M5T15_01640) 342732..343604 + 873 WP_003860347.1 23S rRNA pseudouridine(2604) synthase RluF -
M5T15_RS01645 (M5T15_01645) 343605..343877 - 273 WP_017382612.1 DUF3811 domain-containing protein -
M5T15_RS01650 (M5T15_01650) 343928..344872 - 945 WP_015570166.1 ketopantoate/pantoate/pantothenate transporter PanS -
M5T15_RS01655 (M5T15_01655) 344966..346315 - 1350 WP_006810501.1 lysine-sensitive aspartokinase 3 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-93)

Antitoxin

Uncharacterized protein HI1420

(3-90)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11425.18 Da        Isoelectric Point: 10.3736

>T255167 WP_015570164.1 NZ_CP103494:c342534-342232 [Enterobacter hormaechei]
MKEIVQTESFRRWEQNLKDRRAKTIIASRLFRLANGLAGDIRPVGEGISELRIHFGPGYRIYFKDQGNSIIVLLCGGDKS
SQARDILMAKMLSNVSQWQE

Download         Length: 303 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10101.59 Da        Isoelectric Point: 5.7807

>AT255167 WP_023295755.1 NZ_CP103494:c342225-341938 [Enterobacter hormaechei]
MHKLTPYDPANALLDDEEIAVFMADALETGDSAYIAKALGVIARAKGMSTISQQTGLSREQLYRSFSDKGNPTLKTTLAV
MKALGLGLTIKPSGD

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7G3EX93

Antitoxin

Source ID Structure

References