Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2647048..2648636 Replicon chromosome
Accession NZ_CP103487
Organism Klebsiella quasipneumoniae subsp. quasipneumoniae strain 5463

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag M5T26_RS12905 Protein ID WP_101990367.1
Coordinates 2647048..2648370 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A2N4W0X3
Locus tag M5T26_RS12910 Protein ID WP_023289667.1
Coordinates 2648370..2648636 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T26_RS12890 (2642080) 2642080..2644605 + 2526 WP_214632726.1 fimbria/pilus outer membrane usher protein -
M5T26_RS12895 (2644593) 2644593..2645597 + 1005 WP_130952623.1 fimbrial protein -
M5T26_RS12900 (2645739) 2645739..2647031 + 1293 WP_044523014.1 glycoside hydrolase family 10 protein -
M5T26_RS12905 (2647048) 2647048..2648370 - 1323 WP_101990367.1 type II toxin-antitoxin system HipA family toxin Toxin
M5T26_RS12910 (2648370) 2648370..2648636 - 267 WP_023289667.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
M5T26_RS12915 (2648957) 2648957..2649283 - 327 WP_044523006.1 hydroxyisourate hydrolase -
M5T26_RS12920 (2649280) 2649280..2649780 - 501 WP_032452825.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
M5T26_RS12925 (2649758) 2649758..2651137 - 1380 WP_065812518.1 nucleobase:cation symporter-2 family protein -
M5T26_RS12930 (2651483) 2651483..2652637 + 1155 WP_214632727.1 FAD-dependent urate hydroxylase HpxO -
M5T26_RS12935 (2652618) 2652618..2653541 - 924 WP_214632728.1 LysR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49239.60 Da        Isoelectric Point: 8.9176

>T255161 WP_101990367.1 NZ_CP103487:c2648370-2647048 [Klebsiella quasipneumoniae subsp. quasipneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDDEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLAALRWQTLDEAQLTALLTAYQSDIPLGMVTGQDDFRISVAGAQEKTAL
LRMGEHWCIPQGTTPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARALGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGIPSSMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSLFLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATRGRKTEINAIYPRHFLATAKAVNFPRDQMLAILDEFADRVP
QAIESARRTLPVDFSAHVWRAITENMLKLHARLRQGLQAR

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9891.25 Da        Isoelectric Point: 7.3163

>AT255161 WP_023289667.1 NZ_CP103487:c2648636-2648370 [Klebsiella quasipneumoniae subsp. quasipneumoniae]
MHSPQIYSPVQLANYLKLLRQQNHWTQEALASRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKPAETATAP
DNTTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2N4W0X3

References