Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 791095..791752 Replicon chromosome
Accession NZ_CP103487
Organism Klebsiella quasipneumoniae subsp. quasipneumoniae strain 5463

Toxin (Protein)


Gene name cptA Uniprot ID A0A2N4VX63
Locus tag M5T26_RS03920 Protein ID WP_023290968.1
Coordinates 791342..791752 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag M5T26_RS03915 Protein ID WP_002916312.1
Coordinates 791095..791361 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T26_RS03890 (786245) 786245..787678 - 1434 WP_064158015.1 6-phospho-beta-glucosidase -
M5T26_RS03895 (787797) 787797..788525 - 729 WP_032454033.1 MurR/RpiR family transcriptional regulator -
M5T26_RS03900 (788576) 788576..788887 + 312 WP_064158016.1 N(4)-acetylcytidine aminohydrolase -
M5T26_RS03905 (789051) 789051..789710 + 660 WP_008806429.1 hemolysin III family protein -
M5T26_RS03910 (789866) 789866..790849 - 984 WP_064158017.1 tRNA-modifying protein YgfZ -
M5T26_RS03915 (791095) 791095..791361 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
M5T26_RS03920 (791342) 791342..791752 + 411 WP_023290968.1 protein YgfX Toxin
M5T26_RS03925 (791759) 791759..792280 - 522 WP_004205324.1 flavodoxin FldB -
M5T26_RS03930 (792381) 792381..793277 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
M5T26_RS03935 (793300) 793300..794013 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
M5T26_RS03940 (794019) 794019..795752 + 1734 WP_032454029.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16075.89 Da        Isoelectric Point: 11.4778

>T255156 WP_023290968.1 NZ_CP103487:791342-791752 [Klebsiella quasipneumoniae subsp. quasipneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDPGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT255156 WP_002916312.1 NZ_CP103487:791095-791361 [Klebsiella quasipneumoniae subsp. quasipneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2N4VX63

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References