255155

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsxAB/MqsA(antitoxin)
Location 4214..4722 Replicon plasmid pMB9635_3
Accession NZ_CP103482
Organism Escherichia coli strain 4621

Toxin (Protein)


Gene name TsxA Uniprot ID -
Locus tag M5T46_RS26285 Protein ID WP_052962079.1
Coordinates 4468..4722 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name TsxB Uniprot ID -
Locus tag M5T46_RS26280 Protein ID WP_052962080.1
Coordinates 4214..4471 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T46_RS26250 (M5T46_26250) 1..678 + 678 WP_052962071.1 hypothetical protein -
M5T46_RS26255 (M5T46_26255) 1438..1740 - 303 WP_072120077.1 CcgAII protein -
M5T46_RS26260 (M5T46_26260) 1817..2050 - 234 WP_052962084.1 hypothetical protein -
M5T46_RS26265 (M5T46_26265) 2477..2767 - 291 WP_231239181.1 hypothetical protein -
M5T46_RS26270 (M5T46_26270) 3069..3419 - 351 WP_052962082.1 hypothetical protein -
M5T46_RS26275 (M5T46_26275) 3511..3810 - 300 WP_077814927.1 hypothetical protein -
M5T46_RS26280 (M5T46_26280) 4214..4471 - 258 WP_052962080.1 transcriptional regulator Antitoxin
M5T46_RS26285 (M5T46_26285) 4468..4722 - 255 WP_052962079.1 hypothetical protein Toxin
M5T46_RS26290 (M5T46_26290) 4719..5261 - 543 WP_052962078.1 hypothetical protein -
M5T46_RS26295 (M5T46_26295) 5365..5880 - 516 WP_048267080.1 J domain-containing protein -
M5T46_RS26300 (M5T46_26300) 6463..7128 + 666 WP_052962077.1 ParA family protein -
M5T46_RS26305 (M5T46_26305) 7201..7440 + 240 WP_052962076.1 hypothetical protein -
M5T46_RS26310 (M5T46_26310) 7595..7849 + 255 WP_052962075.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
M5T46_RS26315 (M5T46_26315) 7849..8265 + 417 WP_052962074.1 type II toxin-antitoxin system VapC family toxin -
M5T46_RS26320 (M5T46_26320) 8390..8551 - 162 WP_001128311.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..36884 36884


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(8-37)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9923.49 Da        Isoelectric Point: 9.9168

>T255155 WP_052962079.1 NZ_CP103482:c4722-4468 [Escherichia coli]
MRKNKGRLTYYLEMIDEKYHFVKKISSYSKVYTEGKTKTTKRTLSELVFNENEVGAIDFTKNGLKPVDKSILLTMMKEYK
ENET

Download         Length: 255 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9782.25 Da        Isoelectric Point: 7.8841

>AT255155 WP_052962080.1 NZ_CP103482:c4471-4214 [Escherichia coli]
MTIENTPENIKKLRKKIGLTQTECGEIFGVGLSTWQKKEAKTHNQLNLSKGEFEYLLLLAGEHPEYVLCKRGNMTHNEIN
EQLRP

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References