25515

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 722544..723169 Replicon chromosome
Accession NC_015848
Organism Mycobacterium canettii CIPT 140010059

Toxin (Protein)


Gene name vapC Uniprot ID G0TQA0
Locus tag MCAN_RS03205 Protein ID WP_003403218.1
Coordinates 722768..723169 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ36
Locus tag MCAN_RS03200 Protein ID WP_003403213.1
Coordinates 722544..722771 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MCAN_RS03170 717723..717944 - 222 WP_003898525.1 DUF4926 domain-containing protein -
MCAN_RS03175 718086..718691 + 606 WP_003898526.1 hypothetical protein -
MCAN_RS03180 718710..721277 - 2568 WP_014000324.1 SEC-C domain-containing protein -
MCAN_RS03185 721361..722110 + 750 WP_015287871.1 hypothetical protein -
MCAN_RS03190 722107..722349 + 243 WP_003403210.1 hypothetical protein -
MCAN_RS03200 722544..722771 + 228 WP_003403213.1 antitoxin VapB29 Antitoxin
MCAN_RS03205 722768..723169 + 402 WP_003403218.1 type II toxin-antitoxin system ribonuclease VapC29 Toxin
MCAN_RS23045 723298..723381 + 84 Protein_641 galactose-1-phosphate uridylyltransferase -
MCAN_RS03210 723400..724482 + 1083 WP_015287872.1 galactose-1-phosphate uridylyltransferase -
MCAN_RS03215 724479..725570 + 1092 WP_014000327.1 galactokinase -
MCAN_RS23095 725561..725782 + 222 Protein_644 transposase -
MCAN_RS22670 725766..726227 + 462 WP_049805687.1 transposase -
MCAN_RS20780 726553..727062 - 510 WP_015289187.1 hypothetical protein -
MCAN_RS22295 727059..727268 - 210 WP_041181386.1 hypothetical protein -
MCAN_RS03235 727347..728087 - 741 WP_014000329.1 TVP38/TMEM64 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-120)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 13937.76 Da        Isoelectric Point: 5.7441

>T25515 WP_003403218.1 NC_015848:722768-723169 [Mycobacterium canettii CIPT 140010059]
VTVLLDANVLIALVVAEHVHHDAAADWLMASDTGFATCPMTQGSLVRFLVRSGQSAAAARDVVSAVQCTSRHEFWPDALS
FAGVEVAGVVGHRQVTDAYLAQLARSHDGQLATLDSGLAHLHGDVAVLIPTTT

Download         Length: 402 bp

>T25515 NC_015848:722768-723169 [Mycobacterium canettii CIPT 140010059]
GTGACGGTGCTGCTCGACGCCAACGTGCTGATCGCATTGGTGGTCGCCGAGCATGTGCATCATGATGCCGCAGCGGACTG
GCTCATGGCGTCCGACACCGGATTTGCGACCTGCCCGATGACACAAGGAAGCCTGGTTCGATTCCTGGTGCGCTCGGGAC
AGTCCGCGGCGGCGGCTCGGGATGTCGTCAGTGCGGTCCAGTGCACGAGCCGCCACGAATTCTGGCCCGATGCACTCTCT
TTCGCCGGTGTCGAGGTCGCTGGTGTGGTTGGGCACCGGCAGGTGACCGATGCCTACCTTGCCCAGCTCGCGCGAAGCCA
CGACGGGCAGTTGGCGACGCTCGACAGCGGCTTAGCACACCTGCACGGCGACGTCGCGGTACTCATTCCAACGACCACCT
GA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8163.17 Da        Isoelectric Point: 5.6307

>AT25515 WP_003403213.1 NC_015848:722544-722771 [Mycobacterium canettii CIPT 140010059]
VRTTIDLPQDLHKQALAIARDTHRTLSETVADLMRRGLAANRPTALSSDPRTGLPLVSVGTVVTSEDVRSLEDEQ

Download         Length: 228 bp

>AT25515 NC_015848:722544-722771 [Mycobacterium canettii CIPT 140010059]
GTGCGCACTACCATCGACCTGCCGCAAGACCTGCACAAGCAGGCACTGGCGATTGCCCGGGATACGCACCGCACGTTGAG
TGAAACGGTCGCCGACCTCATGCGACGAGGCCTGGCCGCCAACCGCCCTACCGCGTTGTCCTCAGACCCCAGAACGGGAT
TGCCTTTGGTGAGCGTCGGGACCGTCGTGACCTCCGAGGACGTGCGTTCATTAGAGGACGAGCAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQA0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSC9

References